M
Maria Aguad
Researcher at Brigham and Women's Hospital
Publications - 10
Citations - 470
Maria Aguad is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Typing & Whole genome sequencing. The author has an hindex of 7, co-authored 9 publications receiving 394 citations.
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Journal ArticleDOI
Resolving the daratumumab interference with blood compatibility testing.
Claudia I. Chapuy,Rachel T. Nicholson,Maria Aguad,Bjoern Chapuy,Jacob P. Laubach,Paul G. Richardson,Parul Doshi,Richard M. Kaufman +7 more
TL;DR: It is hypothesized that the observed panreactivity reflected DARA binding to CD38 on reagent RBCs, and methods to prevent this binding are investigated.
Journal ArticleDOI
Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle
William J. Lane,Connie M. Westhoff,Jon Michael Uy,Maria Aguad,Robin Smeland-Wagman,Richard M. Kaufman,Heidi L. Rehm,Robert C. Green,Robert C. Green,Leslie E. Silberstein +9 more
TL;DR: Polymorphic sites associated with antigen expression in the primary literature and reference databases are annotated according to nucleotide positions in cDNA, which makes antigen prediction from next‐generation sequencing data challenging, since it uses genomic coordinates.
Journal ArticleDOI
International validation of a dithiothreitol (DTT)-based method to resolve the daratumumab interference with blood compatibility testing.
Claudia I. Chapuy,Maria Aguad,Rachel T. Nicholson,James P. AuBuchon,Claudia S. Cohn,Meghan Delaney,Mark K. Fung,Meredith Unger,Parul Doshi,Michael F. Murphy,Larry J. Dumont,Richard M. Kaufman +11 more
TL;DR: Treating RBCs with dithiothreitol (DTT) eliminates the DARA interference and validates the DTT method for use by blood bank laboratories worldwide.
Journal ArticleDOI
Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study
William J. Lane,William J. Lane,Connie M. Westhoff,Nicholas Gleadall,Nicholas Gleadall,Maria Aguad,Robin Smeland-Wagman,Sunitha Vege,Daimon P. Simmons,Helen Mah,Matthew S. Lebo,Klaudia Walter,Nicole Soranzo,Nicole Soranzo,Emanuele Di Angelantonio,Emanuele Di Angelantonio,John Danesh,David J. Roberts,David J. Roberts,David J. Roberts,Nicholas A. Watkins,Willem H. Ouwehand,Adam S. Butterworth,Adam S. Butterworth,Richard M. Kaufman,Heidi L. Rehm,Leslie E. Silberstein,Leslie E. Silberstein,Robert C. Green,David W. Bates,Carrie L. Blout,Kurt D. Christensen,Allison L. Cirino,Carolyn Y. Ho,Joel B. Krier,Lisa Soleymani Lehmann,Calum A. MacRae,Cynthia C. Morton,Denise L. Perry,Christine E. Seidman,Shamil R. Sunyaev,Jason L. Vassy,Erica F. Schonman,Tiffany T. Nguyen,Eleanor Steffens,Wendi N. Betting,Samuel J. Aronson,Ozge Ceyhan-Birsoy,Kalotina Machini,Heather M. McLaughlin,Danielle R. Azzariti,Ellen A. Tsai,Jennifer Blumenthal-Barby,Lindsay Z. Feuerman,Amy L. McGuire,Kaitlyn B. Lee,Jill O. Robinson,Melody J. Slashinski,Pamela M. Diamond,Kelly Davis,Peter A. Ubel,Peter Kraft,J. Scott Roberts,Judy Garber,Tina Hambuch,Michael F. Murray,Isaac S. Kohane,Sek Won Kong +67 more
TL;DR: By enabling more precise antigen-matching of patients with blood donors, antigen typing based on whole-genome sequencing provides a novel approach to improve transfusion outcomes with the potential to transform the practice of transfusion medicine.
Journal ArticleDOI
Automated typing of red blood cell and platelet antigens from whole exome sequences
William J. Lane,William J. Lane,Sunitha Vege,Helen Mah,Christine Lomas-Francis,Maria Aguad,Robin Smeland-Wagman,Christopher Koch,Jacqueline M. Killian,Cubby L. Gardner,Mauricio De Castro,Matthew S. Lebo,Richard M. Kaufman,Richard M. Kaufman,Robert C. Green,Connie M. Westhoff +15 more
TL;DR: The recently developed automated software (bloodTyper) for determination of RBC and PLT antigens from whole genome sequencing is extended to whole exome sequencing (WES).