Showing papers in "Transfusion in 2019"

TL;DR: Future studies of resuscitation and survival after traumatic injury must include analysis of prehospital deaths to fully understand the outcomes of early interventions.

TL;DR: New insights provide a rationale for updating the 2004 consensus definition of TRALI and help clarify the pathophysiology of this potentially life‐threatening syndrome.

TL;DR: Despite countless advancements in trauma care a survivability gap still exists in the prehospital setting, and shifting resuscitation from the hospital to the point of injury has shown great promise in decreasing mortality among the severely injured.

TL;DR: The experience of the RBC effects and the impact on blood bank testing and transfusion management in a Phase 1 trial of the humanized anti‐CD47 monoclonal antibody Hu5F9‐G4 in relapsed or primary refractory acute myeloid leukemia (AML) is reported.

TL;DR: Drones offer the opportunity of improving health care, particularly in remote and/or underserved environments by decreasing lab testing turnaround times, enabling just‐in‐time lifesaving medical supply/device delivery, and reducing costs of routine prescription care in rural areas.

TL;DR: Evaluated drug interference in pretransfusion testing, determine mitigation strategies, and compare interference with anti‐CD38 (Daratumumab) are compared.

TL;DR: Progress in transfusion safety in the early 2000s was in large part due to intervention by the World Health Organization and other foreign governmental bodies, coupled with an influx of external funding.

TL;DR: In this article, the impact of factors other than storage duration on the metabolic phenotypes of stored RBCs in a multicenter study was investigated, and it was found that increased methionine metabolism and activation of the transsulfuration pathway was noted in samples processed in the center using additive solution 1.

TL;DR: There are about 2.5 to 6.5 million US citizens living with TBI‐related disabilities, and the cost of care is very high.

TL;DR: The historical and contemporary outcomes of HDFN will be described and the modernday risks of alloimmunization and adverse fetal outcomes, including death, caused by these antibodies weighed against the growing evidence demonstrating the importance of early transfusions in traumatically injured and massively bleeding patients are presented.

TL;DR: There exists an urgent need for controlled clinical studies for HPL and for standardization of product definition, and a need for consensus minimum release criteria to allow for better product definition and to limit variability in performance.

TL;DR: Hemostatic function of refrigerated WB stored for 35 days in anticoagulants citrate–phosphate‐dextrose‐adenosine (CPDA‐1), citrate‐phosphATE‐d Extrose (CPD), or citrate-phosphates‐double dextrose (CP2D) is examined.

TL;DR: The current review summarizes the preclinical studies testing MSC EVs as treatment for ALI and other inflammatory lung diseases and suggests novel stem cell–derived therapies, including MSC‐conditioned medium and extracellular vesicles (EVs) released from MSCs, might constitute compelling alternatives.

TL;DR: This study characterized the reproducibility and dynamics of in vitro hemolysis variables from a subset of the 13,403 blood donors enrolled in the RBC‐Omics study.

TL;DR: The change in donor base demographics, human immunodeficiency virus (HIV) detection rates, and transfusion‐transmissible HIV risk is described.

TL;DR: The Red Blood Cell‐Omics study was initiated to build a large data set containing behavioral, genetic, and biochemical characteristics of blood donors with linkage to outcomes of the patients transfused with their donated RBCs.

TL;DR: Cold storage may be a viable means of extending shelf life and improving safety in blood culturing methods, allowing transfusion of potentially contaminated units.

TL;DR: There is recent support for long‐term adverse effects of donor‐recipient sex‐mismatched red blood cell (RBC) transfusion, but short‐term impact is unknown.

TL;DR: It is hypothesized that platelet‐derived mitochondria encapsulated in EVs may represent a reservoir of mtDNA, a recognized DAMP detected in the extracellular milieu in numerous inflammatory conditions and in platelet concentrates.

TL;DR: The first report of intravenous immunoglobulin G (IVIG) use in a patient with spontaneous HIT is presented, and it is shown that heparin‐induced HIT is frequently characterized by a suboptimal response to standard therapies.

TL;DR: High school students 16 to 18 years‐old contribute 10% of the US blood supply andMitigating iron depletion in these donors is important because they continue to undergo physical and neurocognitive development.

TL;DR: Red blood cell (RBC) storage in the blood bank is characterized by the progressive loss of metabolic regulation, a phenomenon that targets energy and antioxidant metabolism.

TL;DR: Cryopreservation extends platelet shelf life from 5 to 7 days to 2 to 4 years, however, only 73 patients have been transfused cryopreserved PLTs in published randomized controlled trials (RCTs), making safety data insufficient for regulatory approval.

TL;DR: The purpose of this study was to evaluate the associations between donation frequency and red blood cell (RBC) storage stability in a racially/ethnically diverse population of blood donors.

TL;DR: This study determined patient groups for whom safety information regarding TXA is lacking due to common exclusion from perioperative TXA trials are determined.

TL;DR: The short shelf‐life of fresh platelets limits their efficient inventory management and availability during a massive transfusion protocol, but risk of insufficient availability can be mitigated by building an inventory of cryopreserved platelets (CPs).

TL;DR: The biologic origins and functional mechanism of CRISPR systems are reviewed and several current and future clinical applications of genome editing are highlighted, including diagnostic detection of genetic sequences associated with pathogens or cancer.

TL;DR: While very low birth weight infants often require multiple red blood cell transfusions, efforts to minimize transfusion‐associated risks have resulted in more restrictive neonatal transfusion practices, whether restrictive transfusion strategies limit transfusions without increasing morbidity and mortality in this population remains unclear.

TL;DR: The use of hPL in standard cell culture protocols could prove to be a promising tool for further development of cell therapy products in animal protein–free systems.

TL;DR: This is the first modern report of a massive transfusion with unrestricted low‐titer group O whole blood (LTOWB) use in a civilian trauma patient.