A
Adam S. Butterworth
Researcher at University of Cambridge
Publications - 254
Citations - 30680
Adam S. Butterworth is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 65, co-authored 204 publications receiving 20980 citations. Previous affiliations of Adam S. Butterworth include University of Manchester & National Institute for Health Research.
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Journal ArticleDOI
Mendelian randomization analysis with multiple genetic variants using summarized data.
TL;DR: It is concluded that Mendelian randomization investigations using summarized data from uncorrelated variants are similarly efficient to those using individual‐level data, although the necessary assumptions cannot be so fully assessed.
Journal ArticleDOI
Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis
Rajiv Chowdhury,Samantha Warnakula,Setor K Kunutsor,Francesca L. Crowe,Heather Ward,Laura Johnson,Oscar H. Franco,Adam S. Butterworth,Nita G. Forouhi,Simon G. Thompson,Kay-Tee Khaw,Dariush Mozaffarian,John Danesh,Emanuele Di Angelantonio +13 more
TL;DR: Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats.
Journal ArticleDOI
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William J. Astle,Heather Elding,Heather Elding,Tao Jiang,Dave Allen,Dace Ruklisa,Dace Ruklisa,Alice L. Mann,Daniel Mead,Heleen J. Bouman,Fernando Riveros-Mckay,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,John J. Lambourne,John J. Lambourne,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kate Downes,Kate Downes,Kousik Kundu,Kousik Kundu,Lorenzo Bomba,Kim Berentsen,John Bradley,John Bradley,Louise C. Daugherty,Louise C. Daugherty,Olivier Delaneau,Kathleen Freson,Stephen F. Garner,Stephen F. Garner,Luigi Grassi,Luigi Grassi,Jose A. Guerrero,Jose A. Guerrero,Matthias Haimel,Eva M. Janssen-Megens,Anita Kaan,Mihir A Kamat,Bowon Kim,Amit Mandoli,Jonathan Marchini,Jonathan Marchini,Joost H.A. Martens,Stuart Meacham,Stuart Meacham,Karyn Megy,Karyn Megy,Jared O'Connell,Jared O'Connell,Romina Petersen,Romina Petersen,Nilofar Sharifi,S.M. Sheard,James R Staley,Salih Tuna,Martijn van der Ent,Klaudia Walter,Shuang-Yin Wang,Eleanor Wheeler,Steven P. Wilder,Valentina Iotchkova,Valentina Iotchkova,Carmel Moore,Jennifer G. Sambrook,Jennifer G. Sambrook,Hendrik G. Stunnenberg,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Stephen Kaptoge,Stephen Kaptoge,Taco W. Kuijpers,Enrique Carrillo-de-Santa-Pau,David Juan,Daniel Rico,Alfonso Valencia,Lu Chen,Lu Chen,Bing Ge,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yang,Roderic Guigó,Stephan Beck,Dirk S. Paul,Dirk S. Paul,Tomi Pastinen,David Bujold,Guillaume Bourque,Mattia Frontini,Mattia Frontini,Mattia Frontini,John Danesh,David J. Roberts,David J. Roberts,Willem H. Ouwehand,Adam S. Butterworth,Adam S. Butterworth,Adam S. Butterworth,Nicole Soranzo +103 more
TL;DR: A genome-wide association analysis in the UK Biobank and INTERVAL studies is performed, providing evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations betweenBlood cell indices and cardiovascular disease may be non-causal.
Journal ArticleDOI
Genomic atlas of the human plasma proteome.
Benjamin B. Sun,Joseph C. Maranville,James E. Peters,James E. Peters,David Stacey,James R Staley,James A. Blackshaw,Stephen Burgess,Tao Jiang,Ellie Paige,Ellie Paige,Praveen Surendran,Clare Oliver-Williams,Mihir A Kamat,Bram P. Prins,Sheri K. Wilcox,Erik S Zimmerman,An Chi,Narinder Bansal,Narinder Bansal,Sarah L. Spain,Angela M. Wood,Nicholas W. Morrell,Nicholas W. Morrell,John Bradley,Nebojsa Janjic,David J. Roberts,David J. Roberts,Willem H. Ouwehand,John A. Todd,Nicole Soranzo,Karsten Suhre,Dirk S. Paul,Caroline S. Fox,Robert M. Plenge,John Danesh,John Danesh,Heiko Runz,Adam S. Butterworth +38 more
TL;DR: The genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study is characterized, and it is shown that protein quantitative trait loci overlap with gene expression quantitative traits, as well as with disease-associated loci, and evidence that protein biomarkers have causal roles in disease is found.
Journal ArticleDOI
C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction
Stephen Kaptoge,Emanuele Di Angelantonio,Lisa Pennells,Angela M. Wood,Ian R. White,Pei Gao,Matthew G. Walker,Alexander M. W. Cargill Thompson,Nadeem Sarwar,Muriel J. Caslake,Adam S. Butterworth,Philippe Amouyel,Gerd Assmann,Stephan J. L. Bakker,Elizabeth L M Barr,Elizabeth Barrett-Connor,Emelia J. Benjamin,Cecilia Björkelund,Hermann Brenner,Eric J. Brunner,Robert Clarke,Jackie A. Cooper,Peter Cremer,Mary Cushman,Gilles R. Dagenais,Ralph B. D'Agostino,Rachel Dankner,George Davey-Smith,Dorly J. H. Deeg,Jacqueline M. Dekker,Gunnar Engström,Aaron R. Folsom,F. Gerry R. Fowkes,John Gallacher,J. Michael Gaziano,Simona Giampaoli,Richard F. Gillum,Albert Hofman,Barbara V. Howard,Erik Ingelsson,Hiroyasu Iso,Torben Jørgensen,Stefan Kiechl,Akihiko Kitamura,Yutaka Kiyohara,Wolfgang Koenig,Daan Kromhout,Lewis H. Kuller,Debbie A Lawlor,Tom W. Meade,Aulikki Nissinen,Børge G. Nordestgaard,Altan Onat,Demosthenes B. Panagiotakos,Bruce M. Psaty,Beatriz L. Rodriguez,Annika Rosengren,Veikko Salomaa,Jussi Kauhanen,Jukka T. Salonen,Jonathan A. Shaffer,Steven Shea,Ian Ford,Coen D.A. Stehouwer,Timo E. Strandberg,Robert W. Tipping,Alberto Tosetto,Sylvia Wassertheil-Smoller,Patrik Wennberg,Rudi G. J. Westendorp,Peter H. Whincup,Lars Wilhelmsen,Mark Woodward,Gordon D.O. Lowe,Nicholas J. Wareham,Kay-Tee Khaw,Naveed Sattar,Chris J. Packard,Vilmundur Gudnason,Paul M. Ridker,Mark B. Pepys,Simon G. Thompson,John Danesh +82 more
TL;DR: It is estimated that under current treatment guidelines, assessment of the CRP or fibrinogen level in people at intermediate risk for a cardiovascular event could help prevent one additional event over a period of 10 years for every 400 to 500 people screened.