M
Maria Eugenia Guicciardi
Researcher at Mayo Clinic
Publications - 52
Citations - 5444
Maria Eugenia Guicciardi is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Apoptosis & Liver injury. The author has an hindex of 27, co-authored 52 publications receiving 4927 citations. Previous affiliations of Maria Eugenia Guicciardi include University of Modena and Reggio Emilia.
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Journal ArticleDOI
NOTCH3 expression is linked to breast cancer seeding and distant metastasis
Alexey A. Leontovich,Mohammad Jalalirad,Jeffrey L. Salisbury,Lisa D. Mills,Candace L. Haddox,Mark A. Schroeder,Ann C. Mladek Tuma,Maria Eugenia Guicciardi,Luca Zammataro,Mario W. Gambino,Angela Amato,Aldo Di Leonardo,James A. McCubrey,Carol A. Lange,Minetta C. Liu,Tufia C. Haddad,Matthew Bidwell Goetz,Judy C. Boughey,Jann N. Sarkaria,Liewei Wang,James N. Ingle,Evanthia Galanis,Antonino B. D'Assoro +22 more
TL;DR: The key role of NOTCH3 oncogenic signaling in the genesis of breast cancer metastasis is demonstrated and provided a compelling preclinical rationale for the design of novel therapeutic strategies that will selectively target NotCH3 to halt metastatic seeding and to improve the clinical outcomes of patients with breast cancer.
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Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)
Nathan W. Werneburg,Steve F. Bronk,Maria Eugenia Guicciardi,Laurel Thomas,Jimmy D. Dikeakos,Gary Thomas,Gregory J. Gores +6 more
TL;DR: It is reported that TRAIL induces recruitment of the multifunctional sorting protein phosphofurin acidic cluster sorting protein-2 (PACS-2) to DR5-positive endosomes in Huh-7 cells where it forms an immunoprecipitatable complex with Bim and Bax on lysosomal membranes.
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cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.
TL;DR: It is demonstrated that lysosomal permeabilization contributes to TRAIL-induced apoptosis of hepatocellular carcinoma cells and suggested that cFLIP(L) cytoprotection is, in part, due to p42/44 MAPK-dependent inhibition of lysOSomal breakdown.
Journal ArticleDOI
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
Maria Eugenia Guicciardi,Justin L. Mott,Steven F. Bronk,Satoshi Kurita,Christian D. Fingas,Gregory J. Gores +5 more
TL;DR: It is demonstrated that TRAIL-induced apoptosis of liver cancer cells is associated with degradation of cI AP-1 and X-linked IAP (XIAP), whereas cIAP-2 remains unchanged, and results suggest that TRAil-mediated apoptosis proceeds through caspase 8-dependent degradation ofCiAP-1.