M
Maria Georgomanoli
Researcher at National and Kapodistrian University of Athens
Publications - 9
Citations - 266
Maria Georgomanoli is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Induced pluripotent stem cell & Haematopoiesis. The author has an hindex of 8, co-authored 8 publications receiving 221 citations. Previous affiliations of Maria Georgomanoli include Foundation for Biomedical Research & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.
Andrew Wilber,Phillip W. Hargrove,Yoon-Sang Kim,Janice M. Riberdy,Vijay G. Sankaran,Eleni Papanikolaou,Maria Georgomanoli,Nicholas P. Anagnou,Stuart H. Orkin,Arthur W. Nienhuis,Derek A. Persons +10 more
TL;DR: Observations suggest that both lentiviral-mediated γ-globin gene addition and genetic reactivation of endogenous γ,globin genes have potential to provide therapeutic HbF levels to patients with β- globin deficiency.
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Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs
Chan Jung Chang,Andriana G. Kotini,Malgorzata Olszewska,Maria Georgomanoli,Julie Teruya-Feldstein,Henrik Sperber,Roberto Sanchez,Robert J. DeVita,Timothy J. Martins,Omar Abdel-Wahab,Robert K. Bradley,Eirini P. Papapetrou +11 more
TL;DR: In this article, the authors used patient-derived induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing to dissect the individual contributions of two recurrent genetic lesions, the splicing factor SRSF2 P95L mutation and the chromosome 7q deletion, to the development of myeloid malignancy.
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Modeling blood diseases with human induced pluripotent stem cells.
TL;DR: Induced pluripotent stem cells (iPSC) are derived from somatic cells through a reprogramming process, which converts them to a pluripototent state, akin to that of embryonic stem cells.
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Characterization and comparative performance of lentiviral vector preparations concentrated by either one-step ultrafiltration or ultracentrifugation
Eleni Papanikolaou,Georgia Kontostathi,Ekati Drakopoulou,Ekati Drakopoulou,Maria Georgomanoli,Maria Georgomanoli,Evangelos Stamateris,Evangelos Stamateris,Kostas Vougas,Antonia Vlahou,Andrew Maloy,Mark Ware,Nicholas P. Anagnou,Nicholas P. Anagnou +13 more
TL;DR: An improved protocol in which vector stocks are prepared by transient transfection using standard cell culture media and are then concentrated by ultrafiltration, resulting in functional vector titers of up to 6×10 transducing units per millilitre (TU/ml) without the involvement of any purification step is described.
Journal ArticleDOI
Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells
Josephine Wesely,Andriana G. Kotini,Franco Izzo,Hanzhi Luo,Han Yuan,Jun Sun,Maria Georgomanoli,Asaf Zviran,André G. Deslauriers,Neville Dusaj,Stephen D. Nimer,Christina S. Leslie,Dan A. Landau,Michael G. Kharas,Eirini P. Papapetrou +14 more
TL;DR: An LSC gene signature is derived that predicts patient survival and a dependency of LSCs, across AML genotypes, on the RUNX1 transcription factor is uncovered, which can empower efforts to therapeutically target AML L SCs.