M
Maria João Sousa
Researcher at University of Minho
Publications - 126
Citations - 9154
Maria João Sousa is an academic researcher from University of Minho. The author has contributed to research in topics: Yeast & Saccharomyces cerevisiae. The author has an hindex of 33, co-authored 103 publications receiving 8237 citations. Previous affiliations of Maria João Sousa include University of Porto & Centro Hospitalar de Vila Nova de Gaia/Espinho.
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Journal ArticleDOI
Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism.
António Rego,António Rego,Margarida Costa,Margarida Costa,Susana R. Chaves,Nabil Matmati,Helena Pereira,Maria João Sousa,Pedro Moradas-Ferreira,Pedro Moradas-Ferreira,Yusuf A. Hannun,Vítor Costa,Vítor Costa,Manuela Côrte-Real +13 more
TL;DR: It is suggested that ceramide production contributes to cell death induced by acetic acid, especially through hydrolysis of complex sphingolipids catalyzed by Isc1p and de novo synthesis catalystzed by Lag1p, and the first in vivo indication of its involvement in mitochondrial outer membrane permeabilization in yeast is provided.
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Small heat-shock protein Hsp12 contributes to yeast tolerance to freezing stress.
TL;DR: It is shown that overexpression of HSP12 in this tps1Delta strain showed an increase in resistance to freezing storage, indicating that Hsp12p plays a role in freezing tolerance in a way that seems to be interchangeable with trehalose.
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Ammonium Is Toxic for Aging Yeast Cells, Inducing Death and Shortening of the Chronological Lifespan
TL;DR: The data show that NH4 + induces cell death in aging cultures through the regulation of evolutionary conserved pathways, which may provide new insights into longevity regulation in multicellular organisms and increase the understanding of human disorders such as hyperammonemia.
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The genome sequence of the highly acetic acid-tolerant zygosaccharomyces bailii-derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant
Nuno P. Mira,Martin Münsterkötter,Filipa Dias-Valada,Júlia Santos,Margarida Palma,Filipa de Canaveira Roque,Joana F. Guerreiro,Fernando Rodrigues,Maria João Sousa,Cecília Leão,Ulrich Güldener,Isabel Sá-Correia +11 more
TL;DR: The analysis of the genome sequence indicates that strain ISA1307 is an interspecies hybrid between Z. bailii and a closely related species, paving the way to a better understanding of the genetic mechanisms underlying the generation and selection of more robust hybrid yeast strains in the stressful environment of wine fermentations.
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On the capacity of liquid-liquid interfaces
TL;DR: In this paper, an extended mixed-boundary layer exists at the interface, whose thickness extends over several solvent diameters, and it is shown that the interfacial capacity of a large number of liquid-liquid interfaces is larger than predicted by Gouy-Chapman theory.