M
Maria João Sousa
Researcher at University of Minho
Publications - 126
Citations - 9154
Maria João Sousa is an academic researcher from University of Minho. The author has contributed to research in topics: Yeast & Saccharomyces cerevisiae. The author has an hindex of 33, co-authored 103 publications receiving 8237 citations. Previous affiliations of Maria João Sousa include University of Porto & Centro Hospitalar de Vila Nova de Gaia/Espinho.
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Journal ArticleDOI
Hexose transport in Torulaspora delbrueckii: identification of Igt1, a new dual-affinity transporter.
Andreia Pacheco,Lorena Donzella,Lorena Donzella,Maria Jose Hernandez-Lopez,Maria Judite Almeida,Jose Antonio Prieto,Francisca Randez-Gil,John P. Morrissey,Maria João Sousa +8 more
TL;DR: Functional characterization of IGT1 in a Saccharomyces cerevisiae hxt-null strain revealed that it encodes a transporter able to mediate uptake of glucose, fructose and mannose and established that its affinity, as measured by Km, could be modulated by glucose concentration in the medium.
Journal ArticleDOI
KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications
Flávia Couto Brandão Pereira,Anabela Araújo Ferreira,Celso A. Reis,Maria João Sousa,Maria José Oliveira,Ana Preto +5 more
TL;DR: New avenues for investigating the potential of KRAS mutations on inflammatory TME modulation are expected to open, opening a different vision of therapeutic combined approaches to overcome KRAS-associated therapy inefficacy and resistance in cancer.
Journal ArticleDOI
Contacts in Death: The Role of the ER-Mitochondria Axis in Acetic Acid-Induced Apoptosis in Yeast.
Vítor M. Martins,Tânia R. Fernandes,Diana Lopes,Catarina B. Afonso,Maria Rosário Domingues,Manuela Côrte-Real,Maria João Sousa +6 more
TL;DR: It is demonstrated that single ablation of the ERMES components Mdm10p, Mdm12p and Mdm34p increases the resistance of S. cerevisiae to acetic acid-induced apoptosis, which is associated with a prominent delay in the appearance of several apoptotic markers.
Journal ArticleDOI
Improvement of Torulaspora delbrueckii genome annotation: towards the exploitation of genomic features of a biotechnologically relevant yeast
Carolina Santiago,Teresa Rito,Daniel Vieira,Ticiana Fernandes,Célia Pais,Maria João Sousa,Pedro Soares,Ricardo Franco-Duarte +7 more
TL;DR: Torulaspora delbrueckii has attracted interest in recent years due to its properties, ranging from its ability to produce flavor-and aromaenhanced wine to its inability to survive longer in frozen dough.
Journal ArticleDOI
Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probes.
Maria Inês P. S. Leitão,B. Rama Raju,Nuno M. F. S. A. Cerqueira,Maria João Sousa,M. Sameiro T. Gonçalves +4 more
TL;DR: Four new benzo[a]phenoxazinium chlorides with combinations of chloride, ethyl ester and methyl as terminals of the amino substituents were synthesized, demonstrating that changes in the substituent can tailor both their staining specificity and antimicrobial activity.