M
Maria Lucilia dos Santos
Researcher at University of Brasília
Publications - 32
Citations - 525
Maria Lucilia dos Santos is an academic researcher from University of Brasília. The author has contributed to research in topics: Anacardic acids & Cytotoxicity. The author has an hindex of 11, co-authored 31 publications receiving 439 citations. Previous affiliations of Maria Lucilia dos Santos include Federal University of Rio de Janeiro.
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Journal ArticleDOI
Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion.
Geraldino Cunha-Filho,Inês Sabioni Resck,Bruno C. Cavalcanti,Cláudia Pessoa,Manoel Odorico de Moraes,José Roberto de Oliveira Ferreira,Felipe A. R. Rodrigues,Maria Lucilia dos Santos +7 more
TL;DR: The cytotoxic evaluation showed that all natural bufadienolides and their derivatives exhibited moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes.
Journal ArticleDOI
Essential oils: in vitro activity against Leishmania amazonensis , cytotoxicity and chemical composition
Milene Aparecida Andrade,Clênia dos Santos Azevedo,Flávia Nader Motta,Maria Lucilia dos Santos,Camila Lasse Silva,Jaime M. Santana,Izabela Marques Dourado Bastos +6 more
TL;DR: The EO from F. galbaniflua showed to be effective against L. amazonensis promastigotes forms and presented low cytotoxic activity against L6 cells, which represents a strong candidate for future studies aiming its molecular activity on these pathogenic parasites.
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Utilisation of Cashew Nut Shell Liquid from Anacardium occidentale as Starting Material for Organic Synthesis: A Novel Route to Lasiodiplodin from Cardols
TL;DR: In this paper, the conversion of cardols (6-alkenylresorcinols) into lasiodiplodin, a naturally occurring 12-membered orsellinic acid type macrolide, which exhibits plant growth regulating and antileukemic properties, is described.
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Synthesis and cytotoxicity screening of substituted isobenzofuranones designed from anacardic acids.
Lucio Paulo Lima Logrado,Camila O. Santos,Luiz Antonio Soares Romeiro,Arinice M. Costa,José Roberto de Oliveira Ferreira,Bruno C. Cavalcanti,O. Manoel de Moraes,Letícia V. Costa-Lotufo,Cláudia Pessoa,Maria Lucilia dos Santos +9 more
TL;DR: Analysis of mechanisms involved in the cytotoxic activity showed that active compounds were leading to DNA damage, triggering apoptosis or necrosis induction, and interestingly, 1a exhibits significant antiproliferative effect against HL-60 cells and moderate activity against SF295 and MDA-MB435 cell lines.
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Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation
Natália Araújo Touza,Elisa Suzana Carneiro Pôças,Luis Eduardo M. Quintas,Geraldino Cunha-Filho,Maria Lucilia dos Santos,François Noël +5 more
TL;DR: Analyses of inhibition curves showed that the experimental curves for all combinations were superimposed on the theoretical additive curves indicating that an additive effect occurs among distinct cardenolides and bufadienolides combinations on the human α1β1 Na(+)/K(+)-ATPase protomer.