M
Maria Luisa Esposito
Publications - 11
Citations - 1140
Maria Luisa Esposito is an academic researcher. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 8, co-authored 11 publications receiving 1020 citations.
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Journal ArticleDOI
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man
Eleanor Barnes,Eleanor Barnes,Antonella Folgori,Stefania Capone,Leo Swadling,Stephen Aston,Ayako Kurioka,Joel Meyer,Rachel Huddart,Kira Smith,Rachel Townsend,Anthony Brown,Richard D Antrobus,Virginia Ammendola,M. Naddeo,Geraldine O'Hara,C Willberg,Abby Harrison,Fabiana Grazioli,Maria Luisa Esposito,Loredana Siani,Cinzia Traboni,Ye Oo,David H. Adams,Adrian V. S. Hill,Adrian V. S. Hill,Stefano Colloca,Alfredo Nicosia,Riccardo Cortese,Paul Klenerman,Paul Klenerman +30 more
TL;DR: It is demonstrated that vaccines developed with adenoviral vectors can induce broad and sustained immune responses to HCV in humans and open the way for studies of prophylactic and therapeutic vaccines for HCV.
Journal ArticleDOI
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory.
Leo Swadling,Stefania Capone,Richard D Antrobus,Anthony Brown,Rachel Richardson,Evan W. Newell,Evan W. Newell,John Halliday,John Halliday,Christabel Kelly,Christabel Kelly,Dan Hameiri Bowen,Joannah R. Fergusson,Ayako Kurioka,Virginia Ammendola,Mariarosaria Del Sorbo,Fabiana Grazioli,Maria Luisa Esposito,Loredana Siani,Cinzia Traboni,Adrian V. S. Hill,Stefano Colloca,Mark M. Davis,Alfredo Nicosia,Riccardo Cortese,Antonella Folgori,Paul Klenerman,Paul Klenerman,Eleanor Barnes,Eleanor Barnes +29 more
TL;DR: A first-in-human trial of a prime-boost vaccine strategy for HCV, with durable, broad, sustained, and balanced T cell responses, characteristic of those associated with viral control, paving the way for the first efficacy studies of a prophylactic HCV vaccine.
Journal ArticleDOI
Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species
Stefano Colloca,Eleanor Barnes,Antonella Folgori,Virginia Ammendola,Stefania Capone,Agostino Cirillo,Loredana Siani,M. Naddeo,Fabiana Grazioli,Maria Luisa Esposito,Maria Raffaella Ambrosio,Angela Sparacino,M. Bartiromo,Annalisa Meola,Kira Smith,Ayako Kurioka,Geraldine O'Hara,Katie J. Ewer,Nicholas A. Anagnostou,Carly M. Bliss,Adrian V. S. Hill,Cinzia Traboni,Paul Klenerman,Riccardo Cortese,Alfredo Nicosia +24 more
TL;DR: It is shown that rare serotypes of human adenoviruses, which should not be neutralized in most humans, are far less potent as vaccine vectors than Ad5 in mice and nonhuman primates, casting doubt on their potential efficacy in humans.
Journal ArticleDOI
Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans.
Christabel Kelly,Leo Swadling,Stefania Capone,Anthony Brown,Rachel Richardson,John Halliday,Annette von Delft,Ye Htun Oo,David Mutimer,Ayako Kurioka,Felicity Hartnell,Jane Collier,Virginia Ammendola,Mariarosaria Del Sorbo,Fabiana Grazioli,Maria Luisa Esposito,Stefania Di Marco,Loredana Siani,Cinzia Traboni,Adrian V. S. Hill,Stefano Colloca,Alfredo Nicosia,Riccardo Cortese,Antonella Folgori,Paul Klenerman,Eleanor Barnes +25 more
TL;DR: Vaccination with potent HCV adenoviral vectored vaccines fails to restore T‐ cell immunity except where there is genetic mismatch between vaccine immunogen and endogenous virus; this highlights the major challenge of overcoming T‐cell exhaustion in the context of persistent antigen exposure with implications for cancer and other persistent infections.
Journal ArticleDOI
Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates
Angiolo Pierantoni,Maria Luisa Esposito,Virginia Ammendola,Federico Napolitano,Fabiana Grazioli,Adele Abbate,Mariarosaria Del Sorbo,Loredana Siani,Anna Morena D'Alise,Alessandra Taglioni,Gemma Perretta,Antonio G. Siccardi,Elisa Soprana,Maddalena Panigada,Michelle Thom,Elisa Scarselli,Antonella Folgori,Stefano Colloca,Geraldine Taylor,Riccardo Cortese,Alfredo Nicosia,Stefania Capone,Alessandra Vitelli +22 more
TL;DR: It is shown that the vectored RSV vaccine induces potent cellular and humoral responses in a primate model, providing strong support for clinical testing, and generating a new genetic vaccine based on chimpanzee Adenovirus and Modified Vaccinia Ankara RSV, for the induction of neutralizing antibodies and broad cellular immunity.