E
Evan W. Newell
Researcher at Fred Hutchinson Cancer Research Center
Publications - 187
Citations - 17893
Evan W. Newell is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: CD8 & T cell. The author has an hindex of 58, co-authored 175 publications receiving 12772 citations. Previous affiliations of Evan W. Newell include University of Toronto & Agency for Science, Technology and Research.
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Journal ArticleDOI
Dimensionality reduction for visualizing single-cell data using UMAP.
Etienne Becht,Leland McInnes,John Healy,Charles-Antoine Dutertre,Immanuel Kwok,Lai Guan Ng,Florent Ginhoux,Evan W. Newell,Evan W. Newell +8 more
TL;DR: Comparing the performance of UMAP with five other tools, it is found that UMAP provides the fastest run times, highest reproducibility and the most meaningful organization of cell clusters.
Journal ArticleDOI
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni,Etienne Becht,Michael G. Fehlings,Chiew Yee Loh,Si-Lin Koo,Karen Wei Weng Teng,Joe Poh Sheng Yeong,Joe Poh Sheng Yeong,Rahul Nahar,Tong Zhang,Hassen Kared,Kaibo Duan,Nicholas Ang,Michael Poidinger,Yin Yeng Lee,Anis Larbi,Alexis Jiaying Khng,Emile Tan,Cherylin Fu,Ronnie Mathew,Melissa Ching Ching Teo,Wan-Teck Lim,Chee Keong Toh,Boon-Hean Ong,Tina Koh,Axel M. Hillmer,Angela Takano,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Eng Huat Tan,Weiwei Zhai,Daniel Shao-Weng Tan,Daniel Shao-Weng Tan,Iain Beehuat Tan,Iain Beehuat Tan,Iain Beehuat Tan,Evan W. Newell +37 more
TL;DR: It is shown that human lung and colorectal cancer CD8+ TILs can not only be specific for tumour antigens, but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein–Barr virus, human cytomegalovirus or influenza virus).
Journal ArticleDOI
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams,Martin Guilliams,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Charlotte L. Scott,Naomi McGovern,Dorine Sichien,Svetoslav Chakarov,Sofie Van Gassen,Jinmiao Chen,Michael Poidinger,Sofie De Prijck,Simon Tavernier,Ivy Low,Sergio Erdal Irac,Citra Nurfarah Zaini Mattar,Hermi Sumatoh,Gillian Low,Tam John Kit Chung,Dedrick Kok Hong Chan,Ker-Kan Tan,Tony Lim Kiat Hon,Even Fossum,Bjarne Bogen,Mahesh Choolani,Jerry Kok Yen Chan,Anis Larbi,Hervé Luche,Sandrine Henri,Yvan Saeys,Evan W. Newell,Bart N. Lambrecht,Bart N. Lambrecht,Bernard Malissen,Florent Ginhoux +34 more
TL;DR: A universal toolbox for the automated identification of DCs through unsupervised analysis of conventional flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues is provided and validated.
Journal ArticleDOI
Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes
TL;DR: 3D-PCA data showed much greater complexity in the CD8(+) T cell compartment than previously appreciated, including a nearly combinatorial pattern of cytokine expression, with distinct niches occupied by virus-specific cells.
Journal ArticleDOI
TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
Johannes B. Huppa,Markus Axmann,Manuel A. Mörtelmaier,Manuel A. Mörtelmaier,Manuel A. Mörtelmaier,Björn F. Lillemeier,Björn F. Lillemeier,Evan W. Newell,Mario Brameshuber,Lawrence O. Klein,Gerhard J. Schütz,Mark M. Davis,Mark M. Davis +12 more
TL;DR: It is shown that synaptic TCR–pMHC binding dynamics differ significantly from TCR’s binding in solution, and TCR affinity for pMHC was significantly elevated as the result of a large (about 100-fold) increase in the association rate, a likely consequence of complementary molecular orientation and clustering.