Maria Shvedova

TL;DR: According to reviewed literature, JNKs represent promising therapeutic targets for protection of the brain and the heart against ischemic stroke and myocardial infarction, respectively, but different members of the JNK family exert diverse physiological properties which may not allow for systemic administration of non-specific JNK inhibitors for therapeutic purposes.

TL;DR: This review will highlight the changes in chromatin, DNA methylation, and histone alterations that establish and maintain cellular senescence, alongside the specific epigenetic regulation of the senescENCE-associated secretory phenotype (SASP).

TL;DR: It is hypothesize that the disruption of electrical syncytium of the myocardium may underly myocardial stunning and hibernation, and how NO-mediated signaling is involved in myocardian stunning and Siberian hibernation.

TL;DR: A protective role of cGKI is identified in vascular smooth muscle cells during ischemic stroke injury for the first time and was found to be independent of gender and was mediated via improved reperfusion.

TL;DR: The role of miRNAs in skeletal development is discussed, particularly focusing on those whose physiological roles were revealed in vivo, and pathological mechanisms underlining these skeletal dysplasias are discussed.