Maria Soledad Celej

TL;DR: ATR (attenuated total reflection)-FTIR (Fourier-transform infrared) spectroscopy is used, a technique especially sensitive to β-sheet structure, to get a deeper insight into theβ-sheet organization within oligomers and fibrils and the implications of such conformational arrangement for the pathogenicity associated with AS oligomers are discussed.

TL;DR: Five conformers are distinguished among the large number of possible states of the conformational dynamic ensemble: BSA1,8‐ANS, BSA2,6‐ANS', BSAfree, B SAbis‐ans, and BSAunfolded among theLarge number of state-based ligand interactions and the relative population of each distinguishable conformer depends on the type and concentration of ligand and the temperature of the system.

TL;DR: It is suggested that the inflammatory properties of α-syn fibrils are linked to their intrinsic structure, most probably to their cross-β structure, and it is proposed that the canonical fibril-specific cross- β structure represents a new generic motif recognized by the innate immune system.

TL;DR: In vitro assays demonstrated that psychosine, the neurotoxic sphingolipid accumulated in Krabbe disease, accelerated the fibrillization of α‐synuclein, identifying Krab be disease as a new α‐ synucleinopathy.

TL;DR: A novel role for autophagy is demonstrated in the regulation of microglial cell activation and pro-inflammatory molecule secretion, which may be important for the control of inflammatory responses in the CNS and neurotoxicity.