L
Ludovico Cantuti-Castelvetri
Researcher at German Center for Neurodegenerative Diseases
Publications - 27
Citations - 2874
Ludovico Cantuti-Castelvetri is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Microglia & Remyelination. The author has an hindex of 13, co-authored 22 publications receiving 1399 citations. Previous affiliations of Ludovico Cantuti-Castelvetri include Max Planck Society & Technische Universität München.
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Journal ArticleDOI
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Ludovico Cantuti-Castelvetri,Ludovico Cantuti-Castelvetri,Ravi Ojha,Liliana D. Pedro,Liliana D. Pedro,Minou Djannatian,Minou Djannatian,Jonas Franz,Suvi Kuivanen,Franziska van der Meer,Katri Kallio,Tuğberk Kaya,Tuğberk Kaya,Tuğberk Kaya,Maria Anastasina,Maria Anastasina,Teemu Smura,Lev Levanov,Leonora Szirovicza,Allan Tobi,Hannimari Kallio-Kokko,Pamela Österlund,Merja Joensuu,Frederic A. Meunier,Sarah J. Butcher,Sarah J. Butcher,Martin Sebastian Winkler,Brit Mollenhauer,Ari Helenius,Ozgun Gokce,Tambet Teesalu,Tambet Teesalu,Tambet Teesalu,Jussi Hepojoki,Jussi Hepojoki,Olli Vapalahti,Christine Stadelmann,Giuseppe Balistreri,Giuseppe Balistreri,Mikael Simons,Mikael Simons +40 more
TL;DR: It is found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1.
Journal ArticleDOI
Defective cholesterol clearance limits remyelination in the aged central nervous system
Ludovico Cantuti-Castelvetri,Dirk Fitzner,Dirk Fitzner,Mar Bosch-Queralt,Marie-Theres Weil,Marie-Theres Weil,Minhui Su,Paromita Sen,Torben Ruhwedel,Miso Mitkovski,George Trendelenburg,Dieter Lütjohann,Wiebke Möbius,Wiebke Möbius,Mikael Simons +14 more
TL;DR: It is found that old mice fail to resolve the inflammatory response initiated after myelin damage, and drugs being developed to promote cholesterol clearance in human atherosclerosis lesions may also be good candidates for regenerative medicine in the CNS.
Journal ArticleDOI
White matter aging drives microglial diversity.
Shima Safaiyan,Simon Besson-Girard,Tuğberk Kaya,Ludovico Cantuti-Castelvetri,Ludovico Cantuti-Castelvetri,Lu Liu,Hao Ji,Martina Schifferer,Garyfallia Gouna,Garyfallia Gouna,Fumere Usifo,Nirmal Kannaiyan,Dirk Fitzner,Xianyuan Xiang,Moritz J. Rossner,Matthias Brendel,Ozgun Gokce,Mikael Simons,Mikael Simons +18 more
TL;DR: Using single-cell RNA sequencing from white and gray matter separately, the authors identified white matter-associated microglia (WAMs), which share parts of the disease-associated DAM gene signature and are characterized by activation of genes implicated in phagocytic activity and lipid metabolism.
Journal ArticleDOI
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
Kai Schlepckow,Kathryn M. Monroe,Gernot Kleinberger,Ludovico Cantuti-Castelvetri,Samira Parhizkar,Dan Xia,Michael Willem,Georg Werner,Nadine Pettkus,Bettina Brunner,Alice Sülzen,Brigitte Nuscher,Heike Hampel,Xianyuan Xiang,Regina Feederle,Sabina Tahirovic,Joshua I. Park,Rachel Prorok,Cathal Mahon,Chun-Chi Liang,Ju Shi,Do Jin Kim,Hanna Sabelström,Fen Huang,Gilbert Di Paolo,Mikael Simons,Joseph W. Lewcock,Christian Haass,Christian Haass +28 more
TL;DR: 4D9, which has a stalk region epitope close to the cleavage site, demonstrated dual mechanisms of action by stabilizing TREM2 on the cell surface and reducing its shedding, and concomitantly activating phospho‐SYK signaling, suggesting a protective function by driving microglia toward a disease‐associated state.
Journal ArticleDOI
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
Maryam K. Fard,Franziska van der Meer,Paula Sánchez,Ludovico Cantuti-Castelvetri,Sunit Mandad,Sunit Mandad,Sarah Jäkel,Eugenio F. Fornasiero,Sebastian Schmitt,Marc Ehrlich,Marc Ehrlich,Laura Starost,Laura Starost,Tanja Kuhlmann,Christina Sergiou,Verena Schultz,Claudia Wrzos,Wolfgang Brück,Henning Urlaub,Henning Urlaub,Leda Dimou,Leda Dimou,Christine Stadelmann,Mikael Simons +23 more
TL;DR: This work identifies a means to map ongoing myelin formation in health and disease and presents a potential cellular target for remyelination therapies in MS.