M
Maria Spolidoro
Researcher at National Research Council
Publications - 12
Citations - 1444
Maria Spolidoro is an academic researcher from National Research Council. The author has contributed to research in topics: Neuroplasticity & Monocular deprivation. The author has an hindex of 11, co-authored 12 publications receiving 1297 citations.
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Journal ArticleDOI
Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
Alexey Harauzov,Maria Spolidoro,Graziella DiCristo,Roberto De Pasquale,Laura Cancedda,Tommaso Pizzorusso,Alessandro Viegi,Nicoletta Berardi,Lamberto Maffei +8 more
TL;DR: It is found that reduction of GABAergic transmission in the adult rat visual cortex partially reactivates OD plasticity in response to monocular deprivation (MD) and a decrease in the expression of chondroitin sulfate proteoglycans in the visual cortex of MD animals with reduced inhibition is found.
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Nurturing brain plasticity: impact of environmental enrichment.
Laura Baroncelli,Chiara Braschi,Maria Spolidoro,Tatjana Begenisic,Alessandro Sale,Lamberto Maffei +5 more
TL;DR: New light is shed on the potential of EE as a non-invasive strategy to ameliorate deficits in the development of the CNS and to treat neurological disorders.
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Brain plasticity and disease: a matter of inhibition.
Laura Baroncelli,M. Chiara Braschi,Maria Spolidoro,Tatjana Begenisic,Lamberto Maffei,Alessandro Sale +5 more
TL;DR: Recent findings showing that the inhibition-excitation balance controls adult brain plasticity and is at the core of the pathogenesis of neurodevelopmental disorders like autism, Down syndrome, and Rett syndrome are summarized.
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Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex
L. De Vivo,Silvia Landi,M. Panniello,Laura Baroncelli,Sabrina Chierzi,Letizia Mariotti,Maria Spolidoro,Tommaso Pizzorusso,Lamberto Maffei,Gian Michele Ratto +9 more
TL;DR: It is shown that a prominent component of the matrix, chondroitin sulfate proteoglycans (CSPGs), restrains morphological changes of dendritic spines in the visual cortex of adult mice and after enzymatic digestion of CSPGs, cortical spines become more motile and express a larger degree of structural and functional plasticity.
Journal ArticleDOI
Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats
José Fernando Maya Vetencourt,Ettore Tiraboschi,Maria Spolidoro,Eero Castrén,Lamberto Maffei +4 more
TL;DR: A key role is suggested for 5‐HT1A receptor and BDNF‐trkB signalling in driving a transitory epigenetic remodelling of chromatin structure that underlies the reactivation of plasticity in the visual system.