Maria Svelto

TL;DR: Recent data support the hypothesis that, in vivo external calcium, through activation of calcium-sensing receptors, modulates the expression/trafficking of AQP2.

TL;DR: It is shown that autophagy is induced in growth-plate chondrocytes during post-natal development and regulates the secretion of type II collagen (Col2), the major component of cartilage ECM, and is identified as a novel effector of FGF signalling in bone.

TL;DR: The results show that aquaporin-4 expression occurs in the chick embryonic brain, in parallel with maturation and functioning of the blood-brain barrier and suggest that there is a close relationship between water transport regulation and brain development.

TL;DR: AQP4 seems to be the major factor responsible for the fast water transport of cultured astrocytes, as in skeletal muscle, AQP4 is a protein involved in cell plasticity and RNA interference could be a new potent tool for studying AQP pathophysiology in those organs and tissues where they are expressed.

TL;DR: This study demonstrates that in the CNS, NMO‐IgG is able to pull down both M1‐ and M23‐AQP4 but experiments performed using cells selectively transfected with M1- or M23-AqP4 and native tissues show NMO'G epitope to be intrinsic in AQP4 assemblies into OAPs.