Maria Svelto

TL;DR: The results demonstrate that a reduction in dystrophin isoforms (Dp71) at glial endfeet leads to an altered development of the BBB, whose no-closure might contribute to the neurological dysfunctions associated with DMD.

TL;DR: The hypothesis that AQP 2 transition in the Golgi apparatus is associated with a PKA‐independent increase in AQP2 phosphorylation at Ser‐256 is supported.

TL;DR: Evidence is provided that AQP influenced swelling kinetics is the main trigger for RVD and in mediating calcium signaling after hypotonic stimulus together with TRPV4, and calcium influx from the extracellular space and/or TRPv4 are not essential for RVA to occur in astrocytes.

TL;DR: This work deeply sequenced whole transcriptome from spinal cord ventral horns of post-mortem ALS human donors affected by the sporadic form of the disease to find strong deregulation of SNAP25 and STX1B at both mRNA and protein levels suggesting impaired synaptic function through SNAP25 reduction as a possible cause of calcium elevation and glutamate excitotoxicity.

TL;DR: The identity and extent of liver glycerol transport is defined and the correlation between hepatic AQP9 expression and Glycerol permeability (Pgly) in AQP 9+/+ wild‐type mice in different nutritional states and circulating insulin levels is evaluated.