Maria Teresa Catanese

TL;DR: It is demonstrated that HCV can be blocked by passive immunization, as well as showing that a recombinant vaccinia virus vector induces humoral immunity and confers partial protection against heterologous challenge.

TL;DR: It is proposed that HCV-induced miR-122 inhibition by HCV RNA may result in global de-repression of host mi R-122 targets, providing an environment fertile for the long-term oncogenic potential of HCV.

TL;DR: An infectious HCV genome with an affinity tag fused to the E2 envelope glycoprotein is generated, allowing for rapid in situ purification of virions and increased particle density that were instrumental for cryo-EM and cryoelectron tomography (cryo-ET).

TL;DR: In this paper, a cell-based fluorescent reporter system was developed to distinguish individual hepatitis C virus-infected cells in live or fixed samples, and demonstrated use of this technology for several previously intractable applications, including live cell imaging of viral propagation and host response, as well as visualizing infection of primary hepatocyte cultures.

TL;DR: This genetically humanized mouse model opens new opportunities to dissect genetically HCV infection in vivo and provides an important preclinical platform for testing and prioritizing drug candidates and may also have utility for evaluating vaccine efficacy.