M
Maria V. Liberti
Researcher at Duke University
Publications - 27
Citations - 3841
Maria V. Liberti is an academic researcher from Duke University. The author has contributed to research in topics: Warburg effect & Pyrimidine metabolism. The author has an hindex of 11, co-authored 24 publications receiving 2360 citations. Previous affiliations of Maria V. Liberti include Rockefeller University & Cornell University.
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Journal ArticleDOI
The Warburg Effect: How Does it Benefit Cancer Cells?
TL;DR: Several proposed explanations for the function of Warburg Effect are analyzed, emphasize their rationale, and discuss their controversies.
Journal ArticleDOI
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.
Marc O. Johnson,Marc O. Johnson,Melissa M. Wolf,Matthew Z. Madden,Gabriela Andrejeva,Ayaka Sugiura,Diana C. Contreras,Damian Maseda,Maria V. Liberti,Katelyn Paz,Rigel J. Kishton,Matthew E. Johnson,Aguirre A. de Cubas,Pingsheng Wu,Gongbo Li,Yongliang Zhang,Dawn C. Newcomb,Andrew D. Wells,Nicholas P. Restifo,W. Kimryn Rathmell,W. Kimryn Rathmell,Jason W. Locasale,Marco L. Davila,Bruce R. Blazar,Jeffrey C. Rathmell,Jeffrey C. Rathmell +25 more
TL;DR: Though GLS deficiency diminished initial T cell activation and proliferation and impaired differentiation of Th17 cells, loss of GLS also increased Tbet to promote differentiation and effector function of CD4 Th1 and CD8 CTL cells.
Journal ArticleDOI
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
Maria V. Liberti,Maria V. Liberti,Ziwei Dai,Suzanne E. Wardell,Joshua A. Baccile,Xiaojing Liu,Xia Gao,Robert Baldi,Mahya Mehrmohamadi,Mahya Mehrmohamadi,Marc O. Johnson,Neel Madhukar,Alexander A. Shestov,Iok In Christine Chio,Olivier Elemento,Jeffrey C. Rathmell,Frank C. Schroeder,Donald P. McDonnell,Jason W. Locasale +18 more
TL;DR: It is shown that differences in rate-controlling enzymes during the Warburg effect (THE AUTHORS), the most prominent hallmark of cancer cell metabolism, can be used to predict a response to targeting glucose metabolism, and establishes a natural product, koningic acid, to be a selective inhibitor of GAPDH.
Journal ArticleDOI
Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
Michael A. Reid,Annamarie E. Allen,Shiyu Liu,Maria V. Liberti,Pei Liu,Xiaojing Liu,Ziwei Dai,Xia Gao,Qian Wang,Ying Liu,Luhua Lai,Jason W. Locasale +11 more
TL;DR: It is shown that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carbon metabolism, independent of its role in serine production, based on a quantitative model.
Journal ArticleDOI
Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity
TL;DR: This study computationally identified two potential allosteric sites and virtually screened compounds that can bind to these sites and successfully identified PHGDH non-NAD+-competingAllosteric inhibitors that attenuate its enzyme activity, selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo.