J
James Stevens
Researcher at National Center for Immunization and Respiratory Diseases
Publications - 105
Citations - 10338
James Stevens is an academic researcher from National Center for Immunization and Respiratory Diseases. The author has contributed to research in topics: Virus & Hemagglutinin (influenza). The author has an hindex of 39, co-authored 105 publications receiving 9517 citations. Previous affiliations of James Stevens include Babraham Institute & University of Cambridge.
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Journal ArticleDOI
New world bats harbor diverse influenza A viruses.
Suxiang Tong,Xueyong Zhu,Yan Li,Mang Shi,Jing Zhang,Melissa Bourgeois,Hua Yang,Xianfeng Chen,Sergio Recuenco,Jorge Gomez,Li-Mei Chen,Adam Johnson,Ying Tao,C. Dreyfus,Wenli Yu,Ryan McBride,Paul J. Carney,Amy T. Gilbert,Jessie Chang,Zhu Guo,Charles T. Davis,James C. Paulson,James Stevens,Charles E. Rupprecht,Charles E. Rupprecht,Edward C. Holmes,Edward C. Holmes,Ian A. Wilson,Ruben O. Donis +28 more
TL;DR: Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
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Printed covalent glycan array for ligand profiling of diverse glycan binding proteins
Ola Blixt,Steve Head,Tony S. Mondala,Christopher N. Scanlan,Margaret E. Huflejt,Richard Alvarez,Marian C. Bryan,Fabio Fazio,Daniel A. Calarese,James Stevens,Nahid Razi,D.J. Stevens,John J. Skehel,Irma van Die,Dennis R. Burton,Ian A. Wilson,Richard D. Cummings,Nicolai V. Bovin,Chi-Huey Wong,James C. Paulson +19 more
TL;DR: A glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins.
Journal ArticleDOI
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
James Stevens,Ola Blixt,Terrence M. Tumpey,Jeffery K. Taubenberger,James C. Paulson,Ian A. Wilson +5 more
TL;DR: The hemagglutinin structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA, which suggests a path for this H 5N1 virus to gain a foothold in the human population.
Journal ArticleDOI
Glycan Microarray Analysis of the Hemagglutinins from Modern and Pandemic Influenza Viruses Reveals Different Receptor Specificities
James Stevens,Ola Blixt,Laurel Glaser,Jeffery K. Taubenberger,Peter Palese,James C. Paulson,Ian A. Wilson +6 more
TL;DR: The species barrier, as defined by the receptor specificity preferences of 1918 human viruses compared to likely avian virus progenitors, can be circumvented by changes at only two positions in the HA receptor binding site.
Journal ArticleDOI
Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus
James Stevens,Adam L. Corper,Christopher F. Basler,Jeffery K. Taubenberger,Peter Palese,Ian A. Wilson +5 more
TL;DR: A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses that may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.