Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

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Modern Applied Statistics With S

Roles moleculaires des proteines de choc thermique dans le fonctionnement des organismes a des temperatures normales et suite a des chocs thermiques; differents genes impliques

The heat-shock proteins

BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

As a discipline, phylogenetics is becoming transformed by a flood of molecular data. These data allow broad questions to be asked about the history of life, but also present difficult statistical and computational problems. Bayesian inference of phylogeny brings a new perspective to a number of outstanding issues in evolutionary biology, including the analysis of large phylogenetic trees and complex evolutionary models and the detection of the footprint of natural selection in DNA sequences.

https://science.sciencemag.org/content/sci/294/5550/2310.full.pdf

Bayesian inference of phylogeny and its impact on evolutionary biology

Male accessory gland molecules inhibit harmonic convergence in the mosquito Aedes aegypti.

Aedes aegypti mosquitoes are the primary vectors of numerous viruses that impact human health. As manipulation of reproduction has been proposed to suppress mosquito populations, elucidation of biological processes that enable males and females to successfully reproduce is necessary. One essential process is female sperm storage in specialized structures called spermathecae. Aedes aegypti females typically mate once, requiring them to maintain sperm viably to fertilize eggs they lay over their lifetime. Spermathecal gene products are required for Drosophila sperm storage and sperm viability, and a spermathecal-derived heme peroxidase is required for long-term Anopheles gambiae fertility. Products of the Ae. aegypti spermathecae, and their response to mating, are largely unknown. Further, although female blood-feeding is essential for anautogenous mosquito reproduction, the transcriptional response to blood-ingestion remains undefined in any reproductive tissue. We conducted an RNAseq analysis of spermathecae from unfed virgins, mated only, and mated and blood-fed females at 6, 24, and 72 h post-mating and identified significant differentially expressed genes in each group at each timepoint. A blood-meal following mating induced a greater transcriptional response in the spermathecae than mating alone. This study provides the first view of elicited mRNA changes in the spermathecae by a blood-meal in mated females.

/pdf/mating-and-blood-feeding-induce-transcriptome-changes-in-the-qkl9gzi7s3.pdf

Mating and blood-feeding induce transcriptome changes in the spermathecae of the yellow fever mosquito Aedes aegypti.

Upon mating, Drosophila melanogaster females undergo numerous alterations in their behavior and reproductive physiology that are accompanied by small-magnitude transcript-level changes in up to 1700 genes. Many of these postmating transcriptome changes are the direct result of the sperm and seminal fluid proteins (Acps) that females receive from their mates. To begin to determine if the genetic background of the female's mate contributes to the previously described gene expression changes, we assessed whether interactions between the genotypes of two commonly used laboratory strains of D. melanogaster (Canton-S and Oregon R) influence the female's postmating transcriptome as well as several pre- and postcopulatory phenotypes. We find negligible differences in the female's transcriptome at 1-3 hr postmating regardless of the strain of the male with whom she mated. However, a male x female genotype interaction significantly influenced mate selection, and, in some cases, fecundity, fertility, and hatchability. Our data support previous work suggesting that many of the early postmating changes observed in D. melanogaster females are not caused by large modifications of transcript levels. Instead, early postmating phenotypes result from preexisting receptors or pathways that are already in place upon sexual maturity.

https://www.genetics.org/content/genetics/181/4/1273.full.pdf

Strain-Dependent Differences in Several Reproductive Traits Are Not Accompanied by Early Postmating Transcriptome Changes in Female Drosophila melanogaster

Dramatic changes occur in nuclear organization and function during the critical developmental transition from meiosis to mitosis. The Drosophila nuclear lamina protein YA binds to chromatin and is uniquely required for this transition. In this study, we dissected YA's binding to chromatin. We found that YA can bind to chromatin directly and specifically. It binds to DNA but not RNA, with a preference for double-stranded DNA (linear or supercoiled) over single-stranded DNA. It also binds to histone H2B. YA's binding to DNA and histone H2B is mediated by four domains distributed along the length of the YA molecule. A model for YA function at the end of Drosophila female meiosis is proposed.

/pdf/the-drosophila-nuclear-lamina-protein-ya-binds-to-dna-and-1j7de4rk6a.pdf

Mariana F. Wolfner

Papers

Male accessory gland molecules inhibit harmonic convergence in the mosquito Aedes aegypti.

Mating and blood-feeding induce transcriptome changes in the spermathecae of the yellow fever mosquito Aedes aegypti.

Strain-Dependent Differences in Several Reproductive Traits Are Not Accompanied by Early Postmating Transcriptome Changes in Female Drosophila melanogaster

The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains.

Sex Determination: Sex on the Brain?