J
Jonathan Lerner
Researcher at University of Pennsylvania
Publications - 16
Citations - 786
Jonathan Lerner is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chromatin & Transcription factor. The author has an hindex of 8, co-authored 13 publications receiving 629 citations. Previous affiliations of Jonathan Lerner include Paris Descartes University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression
Marianela Candolfi,Marianela Candolfi,James F. Curtin,James F. Curtin,W. Stephen Nichols,Akm Ghulam Muhammad,Gwendalyn D. King,Gwendalyn D. King,G. Elizabeth Pluhar,Elizabeth A. McNiel,John R. Ohlfest,Andrew Freese,Peter F Moore,Jonathan Lerner,Jonathan Lerner,Pedro R. Lowenstein,Pedro R. Lowenstein,Maria G. Castro,Maria G. Castro +18 more
TL;DR: The data indicate that murine models of GBM appear to recapitulate several of the human GBM histopathological features and, considering their reproducibility and availability, they constitute a valuable in vivo system for preclinical studies.
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Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Marianela Candolfi,Kader Yagiz,David Foulad,Gabrielle E. Alzadeh,Matthew Tesarfreund,A.K.M. Ghulam Muhammad,Mariana Puntel,Kurt M. Kroeger,Chunyan Liu,Sharon Lee,James F. Curtin,Gwendalyn D. King,Jonathan Lerner,Katsuaki Sato,Yohei Mineharu,Weidong Xiong,Pedro R. Lowenstein,Maria G. Castro +17 more
TL;DR: The results indicate that Ad-TK+GCV+Ad-Flt3L exhibit the highest efficacy and safety profile among the several proapoptotic approaches tested.
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A changing paradigm of transcriptional memory propagation through mitosis.
TL;DR: Recent data indicate that various transcription factors and RNA polymerase II bind to mitotic chromatin and that thousands of genes remain transcriptionally active in mitosis, contradicting the view that mitotic cells are transcriptionally silenced.
Journal ArticleDOI
Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin.
Jonathan Lerner,Pablo Aurelio Gómez-García,Ryan L. McCarthy,Zhe Liu,Melike Lakadamyali,Kenneth S. Zaret +5 more
TL;DR: This analysis shows how the parameters of the mobility of chromatin-bound factors, but not their diffusion behaviors or SMT-residence times within chromatin, distinguish functional characteristics of different Chromatin-interacting proteins.
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Chromatin Scanning by Dynamic Binding of Pioneer Factors
TL;DR: A new single molecule study shows comparable chromatin residence times for FoxA1 and steroid receptors, and concludes that the distinguishing feature of pioneer factors remains nucleosomal access rather than an exceptional residence time in chromatin.