Mariateresa Pugliano

TL;DR: The Platelet Physiology Subcommittee of the Scientific and Standardization Committee (SSC) of the International Society on Thrombosis and Haemostasis formed a working party of experts with the aim of producing a series of consensus recommendations for standardizing LTA, which formed the basis of a consensus document, which is the subject of the present report.

TL;DR: A large, detailed, global survey of light transmission aggregometry practices shows a very high variability in LTA practices worldwide, and, as a consequence, methodological standardization is necessary.

TL;DR: It is suggested that phagocytic clearance of platelets by leukocytes occurs in PV and ET, possibly involving P-selectin-dependent and -independent pathways, thus representing a novel mechanism to remove activated platelets from the circulation.

TL;DR: ANN appears to be a promising tool for vitamin K antagonist maintenance dose prediction, based on the performance of new generation artificial neural networks to predict the warfarin maintenance dose.

TL;DR: In this paper, the authors evaluated the most appropriate conditions for preparing samples of platelet-rich plasma (PRP) for studies of Platelet aggregation by light transmission aggregometry (LTA), and found that platelet aggregation measured by LTA was lower and more variable in PRP prepared at 300×g.