M
Marie-Geneviève Mattei
Researcher at French Institute of Health and Medical Research
Publications - 216
Citations - 16517
Marie-Geneviève Mattei is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Gene & Complementary DNA. The author has an hindex of 69, co-authored 216 publications receiving 15919 citations. Previous affiliations of Marie-Geneviève Mattei include Howard Hughes Medical Institute & University of Dundee.
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Journal ArticleDOI
A new member of the immunoglobulin superfamily--CTLA-4.
Jean-François Brunet,François Denizot,Marie-Françoise Luciani,Magali Roux-Dosseto,Magali Roux-Dosseto,Marie Suzan,Marie-Geneviève Mattei,Pierre Golstein +7 more
TL;DR: CTLA-4 is mainly expressed in activated lymphocytes and is coinduced with T-cell-mediated cytotoxicity in inducible models of this process and could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily.
Journal Article
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.
TL;DR: CTLA-8 may belong to the growing set of virus-captured functionally important cellular genes related to the immune system or to cell death and cell survival, and is discussed in the context of other genes of this herpesvirus homologous to known immunologically active molecules.
Journal Article
CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
Katherine Harper,C Balzano,E Rouvier,Marie-Geneviève Mattei,Marie-Françoise Luciani,Pierre Golstein +5 more
TL;DR: CD28 and CTLA-4 were found to be strikingly similar in most respects, in terms of structure, sequence, expression, and gene location, furthermore in two species, strongly suggesting that their genes are the direct products of a duplication event and raising the possibility of functional homologies between the corresponding proteins.
Journal ArticleDOI
A Novel Lysosome-Associated Membrane Glycoprotein, DC-LAMP, Induced upon DC Maturation, Is Transiently Expressed in MHC Class II Compartment
B de Saint-Vis,Julie Vincent,Stéphane Vandenabeele,Béatrice Vanbervliet,Jean-Jacques Pin,Smina Ait-Yahia,S. Patel,Marie-Geneviève Mattei,Jacques Banchereau,Sandra Zurawski,Jean Davoust,Christophe Caux,Serge Lebecque +12 more
TL;DR: A novel lysosome-associated membrane glycoprotein localized on chromosome 3q26.3-q27, DC-LAMP, which is homologous to CD68, was identified and found in the MHC class II compartment immediately before the translocation of MHCclass II molecules to the cell surface, after which it concentrates into perinuclear l Lysosomes.
Journal ArticleDOI
A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion
Catherine D. Nobes,Inger Lauritzen,Marie-Geneviève Mattei,Sonia Paris,Alan Hall,Pierre Chardin +5 more
TL;DR: It is suggested that three proteins that form a distinct branch of the Rho family control rearrangements of the actin cytoskeleton and changes in cell adhesion, including Rnd1, which has a low affinity for GDP and spontaneously exchanges nucleotide rapidly in a physiological buffer.