M
Marie La Russa
Researcher at Stanford University
Publications - 14
Citations - 3147
Marie La Russa is an academic researcher from Stanford University. The author has contributed to research in topics: CRISPR & Genome. The author has an hindex of 9, co-authored 12 publications receiving 2346 citations. Previous affiliations of Marie La Russa include University of California, San Francisco.
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Journal ArticleDOI
CRISPR/Cas9 in Genome Editing and Beyond
TL;DR: The Cas9 protein, derived from type II CRISPR (clustered regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a powerful tool for engineering the genome in diverse organisms.
Journal ArticleDOI
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
Jesse G. Zalatan,Michael E. Lee,Ricardo Almeida,Luke A. Gilbert,Luke A. Gilbert,Evan H. Whitehead,Marie La Russa,Jordan C. Tsai,Jonathan S. Weissman,John E. Dueber,Lei S. Qi,Wendell A. Lim +11 more
TL;DR: By extending guide RNAs to include effector protein recruitment sites, this work constructs modular scaffold RNAs that encode both target locus and regulatory action and applies this approach to flexibly redirect flux through a complex branched metabolic pathway in yeast.
Journal ArticleDOI
Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Chen Yu,Yanxia Liu,Tianhua Ma,Kai Liu,Shaohua Xu,Yu Zhang,Honglei Liu,Honglei Liu,Marie La Russa,Marie La Russa,Min Xie,Sheng Ding,Lei S. Qi +12 more
TL;DR: A reporter-based screening approach for high-throughput identification of chemical compounds that can modulate precise genome editing through homology-directed repair (HDR) is developed and small molecules that can enhance CRISPR-mediated HDR efficiency are identified.
Journal ArticleDOI
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.
Timothy R. Abbott,Girija Dhamdhere,Yanxia Liu,Xueqiu Lin,Laine E. Goudy,Leiping Zeng,Augustine Chemparathy,Stephen Chmura,Nicholas S. Heaton,Robert J. Debs,Tara Pande,Drew Endy,Marie La Russa,David B. Lewis,Lei S. Qi +14 more
TL;DR: A CRISPR-Cas13-based strategy for viral inhibition that can effectively degrade RNA from SARS-CoV-2 sequences and live influenza A virus in human lung epithelial cells is demonstrated and has the potential to become an important pan-coronavirus inhibition strategy.
Journal ArticleDOI
The New State of the Art: Cas9 for Gene Activation and Repression.
Marie La Russa,Lei S. Qi +1 more
TL;DR: The recent advances of CRISPR-Cas9 technology for gene regulation are described and the advantages and disadvantages of CRisPRa and CRISpri (CRISPRa/i) relative to alternative technologies are outlined.