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Yanxia Liu
Researcher at Stanford University
Publications - 29
Citations - 4371
Yanxia Liu is an academic researcher from Stanford University. The author has contributed to research in topics: CRISPR & Embryonic stem cell. The author has an hindex of 20, co-authored 25 publications receiving 3678 citations. Previous affiliations of Yanxia Liu include Peking University.
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Journal ArticleDOI
Directed differentiation of human embryonic stem cells into functional hepatic cells.
Jun Cai,Yang Zhao,Yanxia Liu,Fei Ye,Zhihua Song,Han Qin,Sha Meng,Yuezhou Chen,Rudan Zhou,Xijun Song,Yushan Guo,Mingxiao Ding,Hongkui Deng +12 more
TL;DR: A novel three‐stage method to efficiently direct the differentiation of human embryonic stem cells into hepatic cells in serum‐free medium is reported, which should facilitate searching the molecular mechanisms underlying human liver development, and form the basis for hepatocyte transplantation and drug tests.
Journal ArticleDOI
Two supporting factors greatly improve the efficiency of human iPSC generation.
Yang Zhao,Xiaolei Yin,Han Qin,Fangfang Zhu,Haisong Liu,Weifeng Yang,Qiang Zhang,Chengang Xiang,Pingping Hou,Zhihua Song,Yanxia Liu,Jun Yong,Pengbo Zhang,Jun Cai,Meng Liu,Honggang Li,Yanqin Li,Xiuxia Qu,Kai Cui,Weiqi Zhang,Tingting Xiang,Yetao Wu,Yiding Zhao,Chun Liu,Chen Yu,Kehu Yuan,Jinning Lou,Mingxiao Ding,Hongkui Deng +28 more
TL;DR: It was found that p53 siRNA and UTF1 enhanced the efficiency of iPSC generation up to 100-fold, even when the oncogene c-MYC was removed from the combinations.
Journal ArticleDOI
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Zhihua Song,Jun Cai,Yanxia Liu,Dongxin Zhao,Jun Yong,Shuguang Duo,Xijun Song,Yushan Guo,Yang Zhao,Han Qin,Xiaolei Yin,Chen Wu,Jie Che,Shichun Lu,Mingxiao Ding,Hongkui Deng +15 more
TL;DR: Results show that human iPS cells, which are similar to human ES cells, can be efficiently induced to differentiate into hepatocyte-like cells.
Journal ArticleDOI
Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Chen Yu,Yanxia Liu,Tianhua Ma,Kai Liu,Shaohua Xu,Yu Zhang,Honglei Liu,Honglei Liu,Marie La Russa,Marie La Russa,Min Xie,Sheng Ding,Lei S. Qi +12 more
TL;DR: A reporter-based screening approach for high-throughput identification of chemical compounds that can modulate precise genome editing through homology-directed repair (HDR) is developed and small molecules that can enhance CRISPR-mediated HDR efficiency are identified.
Journal ArticleDOI
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.
Timothy R. Abbott,Girija Dhamdhere,Yanxia Liu,Xueqiu Lin,Laine E. Goudy,Leiping Zeng,Augustine Chemparathy,Stephen Chmura,Nicholas S. Heaton,Robert J. Debs,Tara Pande,Drew Endy,Marie La Russa,David B. Lewis,Lei S. Qi +14 more
TL;DR: A CRISPR-Cas13-based strategy for viral inhibition that can effectively degrade RNA from SARS-CoV-2 sequences and live influenza A virus in human lung epithelial cells is demonstrated and has the potential to become an important pan-coronavirus inhibition strategy.