Mariela F. Trinchero

TL;DR: It is shown that the adult hippocampal neurogenic lineage is critically dependent on the mitochondrial electron transport chain and oxidative phosphorylation machinery at the stage of the fast proliferating intermediate progenitor cell.

TL;DR: It is shown that local network activity regulates the rate of maturation of adult-born neurons along the septotemporal axis of the hippocampus, revealing a novel type of activity-dependent plasticity acting on the timing of neuronal maturation and functional integration of newly generated neuronsAlong the longitudinalaxis of the adult hippocampus.

TL;DR: It is shown that immature GCs can efficiently drive distal CA3 targets but poorly activate proximal interneurons responsible for feedback inhibition (FBI), and a computational model reveals that the delayed coupling of new GCs to FBI could be crucial to achieve a fine-grain representation of novel inputs in the dentate gyrus.

TL;DR: The results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that “prime” young GCs through a disynaptic feedback loop mediated by PV-INs.

TL;DR: In this paper, the authors investigated the contribution of adult hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders, and found that the hippocampus' performance underlie psychiatric disorders.