J
Jaehoon Shin
Researcher at Johns Hopkins University School of Medicine
Publications - 31
Citations - 4641
Jaehoon Shin is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: DNA methylation & Trigeminal neuralgia. The author has an hindex of 17, co-authored 29 publications receiving 3894 citations. Previous affiliations of Jaehoon Shin include Columbia University Medical Center & Seoul National University.
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Journal ArticleDOI
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Hengli Tang,Christy Hammack,Sarah C. Ogden,Zhexing Wen,Xuyu Qian,Yujing Li,Bing Yao,Jaehoon Shin,Feiran Zhang,Emily M. Lee,Kimberly M. Christian,Ruth Didier,Peng Jin,Hongjun Song,Guo Li Ming +14 more
TL;DR: It is shown that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells (hNPCs) derived from induced pluripotent stem cells, identified as a direct ZikV target, and reveals transcriptional dysregulation, notably of cell-cycle-related pathways.
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Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.
Jaehoon Shin,Daniel A. Berg,Yunhua Zhu,Joseph Y. Shin,Juan Song,Michael A. Bonaguidi,Grigori Enikolopov,David W. Nauen,Kimberly M. Christian,Guo Li Ming,Hongjun Song +10 more
TL;DR: The molecular continuum underlying adult neurogenesis is revealed and Waterfall, a bioinformatic pipeline, is developed to statistically quantify singe-cell gene expression along a de novo reconstructed continuous developmental trajectory.
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Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
Junjie U. Guo,Yijing Su,Joo Heon Shin,Jaehoon Shin,Hongda Li,Bin Xie,Chun Zhong,Shaohui Hu,Thuc T Le,Guoping Fan,Heng Zhu,Qiang Chang,Yuan Gao,Guo Li Ming,Hongjun Song +14 more
TL;DR: The characteristics of CpH methylation suggest that a substantially expanded proportion of the neuronal genome is under cytosine methylation regulation and provide a new foundation for understanding the role of this key epigenetic modification in the nervous system.
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Synaptic dysregulation in a human iPS cell model of mental disorders
Zhexing Wen,Ha Nam Nguyen,Ziyuan Guo,Matthew A. Lalli,Xinyuan Wang,Yijing Su,Namshik Kim,Ki Jun Yoon,Jaehoon Shin,Ce Zhang,Georgia Makri,David W. Nauen,Huimei Yu,Elmer Guzman,Cheng Hsuan Chiang,Nadine Yoritomo,Kozo Kaibuchi,Jizhong Zou,Kimberly M. Christian,Linzhao Cheng,Christopher A. Ross,Russell L. Margolis,Gong Chen,Kenneth S. Kosik,Hongjun Song,Guo Li Ming +25 more
TL;DR: This study reveals that a psychiatric disorder relevant mutation causes synapse deficits and transcriptional dysregulation in human neurons and the findings provide new insight into the molecular and synaptic etiopathology of psychiatric disorders.
Journal ArticleDOI
DNA methylation presents distinct binding sites for human transcription factors
Shaohui Hu,Jun Wan,Yijing Su,Qifeng Song,Yaxue Zeng,Ha Nam Nguyen,Jaehoon Shin,Eric Cox,Hee Sool Rho,Crystal Woodard,Shuli Xia,Shuang Liu,Huibin Lyu,Guo Li Ming,Herschel Wade,Hongjun Song,Jiang Qian,Heng Zhu +17 more
TL;DR: It is suggested that mCpG-dependent TF binding activity is a widespread phenomenon and provides a new framework to understand the role and mechanism of TFs in epigenetic regulation of gene transcription.