A
Alejandro F. Schinder
Researcher at Fundación Instituto Leloir
Publications - 66
Citations - 11093
Alejandro F. Schinder is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: Neurogenesis & Dentate gyrus. The author has an hindex of 34, co-authored 64 publications receiving 10256 citations. Previous affiliations of Alejandro F. Schinder include University of Buenos Aires & Salk Institute for Biological Studies.
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Journal ArticleDOI
Functional neurogenesis in the adult hippocampus
Henriette van Praag,Alejandro F. Schinder,Brian R. Christie,Brian R. Christie,Nicolas Toni,Theo D. Palmer,Theo D. Palmer,Fred H. Gage +7 more
TL;DR: It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.
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Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity
TL;DR: Early mitochondrial damage plays a key role in induction of glutamate neurotoxicity, and blockade of the mitochondrial permeability transition pore by cyclosporin A allows complete recovery of ΔΨ and prevents cell death.
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The neurotrophin hypothesis for synaptic plasticity.
TL;DR: The characteristics of synaptic changes that are induced by neurotrophins suggest that this family of proteins is crucial for providing a molecular background in which activity-dependent plasticity can occur at selective synaptic sites within the neural network.
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Neurons born in the adult dentate gyrus form functional synapses with target cells
Nicolas Toni,Diego Andrés Laplagne,Chunmei Zhao,Gabriela Lombardi,Charles E. Ribak,Fred H. Gage,Alejandro F. Schinder +6 more
TL;DR: Structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.
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GABA Itself Promotes the Developmental Switch of Neuronal GABAergic Responses from Excitation to Inhibition
TL;DR: GABA acts as a self-limiting trophic factor during neural development by modulating the mRNA levels of KCC2, a K(+)-Cl(-) cotransporter whose expression correlates with the switch.