M
Mariella De Biasi
Researcher at University of Pennsylvania
Publications - 81
Citations - 6472
Mariella De Biasi is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Nicotinic agonist & Nicotine. The author has an hindex of 39, co-authored 73 publications receiving 5934 citations. Previous affiliations of Mariella De Biasi include Baylor College of Medicine & University of Padua.
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Journal ArticleDOI
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Avi Orr-Urtreger,Finn M. Göldner,Mayuko Saeki,Isabel Lorenzo,Leah Goldberg,Mariella De Biasi,John A. Dani,James W. Patrick,Arthur L. Beaudet +8 more
TL;DR: It is demonstrated that the α7 subunit is not essential for normal development or for apparently normal neurological function, but the mice may prove to have subtle phenotypic abnormalities and will be valuable in defining the functional role of this gene product in vivo.
Journal ArticleDOI
Principles for the post-GWAS functional characterization of cancer risk loci
Matthew L. Freedman,Alvaro N.A. Monteiro,Simon A. Gayther,Simon A. Gayther,Gerhard A. Coetzee,Angela Risch,Christoph Plass,Graham Casey,Mariella De Biasi,Christopher S. Carlson,David Duggan,Michael A. James,Pengyuan Liu,Jay W. Tichelaar,Haris G. Vikis,Ming You,Ian G. Mills,Ian G. Mills +17 more
TL;DR: In this article, the authors propose principles for the initial functional characterization of cancer risk loci, with a focus on non-coding variants, and define post-GWAS functional characterization.
Journal ArticleDOI
Cellular mechanisms of nicotine addiction.
John A. Dani,Mariella De Biasi +1 more
TL;DR: A portion of nicotine's addictive power is attributable to actions upon the dopaminergic systems, which normally help to reinforce rewarding behaviors and contribute to the cellular events that underlie nicotine addiction.
Journal ArticleDOI
Nicotine Decreases Food Intake Through Activation of POMC Neurons
Yann S. Mineur,Alfonso Abizaid,Yan Rao,Ramiro Salas,Ralph J. DiLeone,Daniela Gündisch,Sabrina Diano,Mariella De Biasi,Tamas L. Horvath,Xiao-Bing Gao,Marina R. Picciotto +10 more
TL;DR: It is demonstrated that nicotine decreases food intake and body weight by influencing the hypothalamic melanocortin system and identifies critical molecular and synaptic mechanisms involved in nicotine-induced decreases in appetite.
Journal ArticleDOI
Reward, Addiction, Withdrawal to Nicotine
Mariella De Biasi,John A. Dani +1 more
TL;DR: Nicotine taps into diverse neural systems and an array of nicotinic acetylcholine receptor (nAChR) subtypes to influence reward, addiction, and withdrawal.