D
David Duggan
Researcher at Translational Genomics Research Institute
Publications - 173
Citations - 18088
David Duggan is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 57, co-authored 167 publications receiving 16574 citations. Previous affiliations of David Duggan include Johns Hopkins University & Lund University.
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Journal ArticleDOI
Expression profiling using cdna microarrays
TL;DR: Technical aspects of cDNA microarrays are reviewed, including the general principles, fabrication of the arrays, target labelling, image analysis and data extraction, management and mining.
Journal ArticleDOI
Gene-Expression Profiles in Hereditary Breast Cancer
Ingrid Hedenfalk,David Duggan,Yi Chen,Michael D. Radmacher,M. Bittner,Richard M. Simon,P. Meltzer,Barry A. Gusterson,Manel Esteller,O. P. Kallioniemi,Benjamin S. Wilfond,Åke Borg,J.M. Trent,Mark Raffeld,Zohar Yakhini,Amir Ben-Dor,Edward R. Dougherty,Juha Kononen,Lukas Bubendorf,W Fehrle,Stefania Pittaluga,Sofia Gruvberger,Niklas Loman,Oskar T. Johannsson,Håkan Olsson,Guido Sauter +25 more
TL;DR: Significantly different groups of genes are expressed by breast cancers with BRCA1 mutations and breast cancersWith BRCa2 mutations, the results suggest that a heritable mutation influences the gene-expression profile of the cancer.
Journal ArticleDOI
Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Nils Homer,Nils Homer,Szabolcs Szelinger,Margot Redman,David Duggan,Waibhav Tembe,Jill Muehling,John V. Pearson,Dietrich A. Stephan,Stanley F. Nelson,David Craig +10 more
TL;DR: High-density single nucleotide polymorphism genotyping microarrays are used to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination.
Journal ArticleDOI
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada,Unnur Styrkarsdottir,Evangelos Evangelou,Yi-Hsiang Hsu,Emma L. Duncan,Evangelia E. Ntzani,Ling Oei,Omar M. E. Albagha,Najaf Amin,John P. Kemp,Daniel L. Koller,Guo Shuai Li,Ching-Ti Liu,Ryan L. Minster,Alireza Moayyeri,Liesbeth Vandenput,Dana Willner,Su-Mei Xiao,Laura M. Yerges-Armstrong,Hou-Feng Zheng,Nerea Alonso,Joel Eriksson,Candace M. Kammerer,Stephen Kaptoge,Paul Leo,Gudmar Thorleifsson,Scott Wilson,Scott Wilson,James F. Wilson,Ville Aalto,Ville Aalto,Markku Alen,Aaron K. Aragaki,Thor Aspelund,Zoe H. Dailiana,David Duggan,Melissa Nolan Garcia,Natalia Garcia-Giralt,Sylvie Giroux,Göran Hallmans,Lynne J. Hocking,L. B. Husted,Karen A. Jameson,Khusainova Ri,Ghi Su Kim,Charles Kooperberg,Theodora Koromila,Marcin Kruk,Marika Laaksonen,Andrea Z. LaCroix,Seung-Hun Lee,P. C. Leung,Joshua R. Lewis,Laura Masi,Simona Mencej-Bedrač,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Millan S. Patel,Janez Prezelj,Lynda M. Rose,Serena Scollen,Kristin Siggeirsdottir,Albert V. Smith,Olle Svensson,Stella Trompet,Olivia Trummer,Natasja M. van Schoor,Jean Woo,Kun Zhu,Susana Balcells,Maria Luisa Brandi,Brendan M. Buckley,Sulin Cheng,Claus Christiansen,Cyrus Cooper,George Dedoussis,Ian Ford,Morten Frost,Morten Frost,David Goltzman,Jesús González-Macías,Mika Kähönen,Magnus Karlsson,Elza Khusnutdinova,Jung-Min Koh,Panagoula Kollia,Bente L. Langdahl,William D. Leslie,Paul Lips,Östen Ljunggren,Roman S. Lorenc,Janja Marc,Dan Mellström,Barbara Obermayer-Pietsch,José M. Olmos,Ulrika Pettersson-Kymmer,David M. Reid,José A. Riancho,Paul M. Ridker,François Rousseau,P. Eline Slagboom,Nelson Ls Tang,Roser Urreizti,Wim Van Hul,Jorma Viikari,María T. Zarrabeitia,Yurii S. Aulchenko,Martha C. Castaño-Betancourt,Elin Grundberg,Elin Grundberg,Lizbeth Herrera,Thorvaldur Ingvarsson,Hrefna Johannsdottir,Tony Kwan,Rui Jian Li,Robert Luben,Carolina Medina-Gomez,Stefan T Palsson,Sjur Reppe,Jerome I. Rotter,Gunnar Sigurdsson,Joyce B. J. van Meurs,Dominique J. Verlaan,Frances M K Williams,Andrew R. Wood,Yanhua Zhou,Kaare M. Gautvik,Tomi Pastinen,Soumya Raychaudhuri,Soumya Raychaudhuri,Jane A. Cauley,Daniel I. Chasman,Graeme R. Clark,Steven R. Cummings,Patrick Danoy,Elaine M. Dennison,Richard Eastell,John A. Eisman,John A. Eisman,Vilmundur Gudnason,Albert Hofman,Rebecca D. Jackson,Graeme Jones,J. Wouter Jukema,Kay-Tee Khaw,Terho Lehtimäki,Yongmei Liu,Mattias Lorentzon,Eugene V. McCloskey,Braxton D. Mitchell,Kannabiran Nandakumar,Geoffrey C. Nicholson,Ben A. Oostra,Munro Peacock,Huibert A. P. Pols,Richard L. Prince,Olli T. Raitakari,Olli T. Raitakari,Ian R. Reid,John A Robbins,Philip N. Sambrook,Pak C. Sham,Alan R. Shuldiner,Frances A. Tylavsky,Cornelia M. van Duijn,Nicholas J. Wareham,L. Adrienne Cupples,Michael J. Econs,David M. Evans,Tamara B. Harris,Annie W.C. Kung,Bruce M. Psaty,Jonathan Reeve,Tim D. Spector,Elizabeth A. Streeten,M. Carola Zillikens,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Claes Ohlsson,David Karasik,J. Brent Richards,Matthew A. Brown,Kari Stefansson,Kari Stefansson,André G. Uitterlinden,Stuart H. Ralston,John P. A. Ioannidis,John P. A. Ioannidis,Douglas P. Kiel,Fernando Rivadeneira +190 more
TL;DR: Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
Journal ArticleDOI
Cumulative Association of Five Genetic Variants with Prostate Cancer
S. Lilly Zheng,Jielin Sun,Fredrik Wiklund,Shelly G. Smith,Pär Stattin,Ge Li,Hans-Olov Adami,Hans-Olov Adami,Fang-Chi Hsu,Yi Zhu,Katarina Bälter,A. Karim Kader,Aubrey R. Turner,Wennuan Liu,Eugene R. Bleecker,Deborah A. Meyers,David Duggan,John D. Carpten,Bao Li Chang,William B. Isaacs,Jianfeng Xu,Henrik Grönberg +21 more
TL;DR: In this paper, single-nucleotide polymorphisms (SNPs) in five chromosomal regions were associated with prostate cancer in a Swedish population, three at 8q24 and one each at 17q12 and 17q24.