Z
Zsuzsa Hadady
Researcher at University of Debrecen
Publications - 7
Citations - 395
Zsuzsa Hadady is an academic researcher from University of Debrecen. The author has contributed to research in topics: Glycogen phosphorylase & Glucose analog. The author has an hindex of 6, co-authored 6 publications receiving 382 citations.
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Journal ArticleDOI
Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents: Recent Developments
TL;DR: Recent developments in the synthesis and evaluation of glucopyranosylidene-spiro-thiohydantoin 18 and further anomerically bifunctional glucose derivatives which may be good inhibitors of GP are surveyed.
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Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.
Evangelia D. Chrysina,Magda Kosmopoulou,Constantinos Tiraidis,Rozina Kardakaris,Nicolas Bischler,Demetres D. Leonidas,Zsuzsa Hadady,László Somsák,Tibor Docsa,Pál Gergely,Nikos G. Oikonomakos +10 more
TL;DR: The complex structures of GPb in complex with the three analogs revealed that the inhibitors can be accommodated in the catalytic site of T‐state GPb with very little change of the tertiary structure, and provide a rationalization for understanding variations in potency of the inhibitors.
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Synthesis of N-(β-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
Zoltán Györgydeák,Zsuzsa Hadady,Nóra Felföldi,Attila Krakomperger,Veronika Nagy,Marietta Tóth,Attila Brunyanszki,Tibor Docsa,Pál Gergely,László Somsák +9 more
TL;DR: In this article, the deprotected compounds obtained by Zemplen deacetylation were evaluated as inhibitors of rabbit muscle glycogen phosphorylase b. The best inhibitor has been N -(β- D -glucopyranosyl) 3-(2-naphthyl)-propenoic amide (K i ǫ = 3.5μM).
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C-(β-D-glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors
TL;DR: In this paper, per-O-acetylated and -benzoylated β-D-glucopyranosyl cyanides were transformed into the corresponding 5-(D-Glucopyrusyl)tetrazoles.
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Synthesis of N-(β-d-glucopyranosyl) monoamides of dicarboxylic acids as potential inhibitors of glycogen phosphorylase
Katalin Czifrák,Zsuzsa Hadady,Tibor Docsa,Pál Gergely,Jürgen Schmidt,Ludger A. Wessjohann,László Somsák +6 more
TL;DR: O-peracetylated N-(beta-D-glucopyranosyl)imino trimethylphosphorane obtained in situ from 2,3,4,6-tetra-O-acetyl-beta- dicarboxylic acids and PMe3 showed moderate inhibitory effects against rabbit muscle glycogen phosphorylase b.