Mario Boccadoro

TL;DR: In this article, the authors demonstrate that the CXCL12/CXCR4 axis plays a pivotal role in the positive regulation of the α subunit of HIF-1 that occurs in CLL cells co-cultured with stromal cells (SC).

TL;DR: This review analyzes the available tools for the assessment of frailty and possible strategies to improve the discriminative power of the scores and expand their use in real-life and clinical trial settings and addresses the main therapeutic challenges in the management of intermediate-fit and frail MM patients at diagnosis and at relapse.

TL;DR: This analysis aimed at comparing MRD data by PET/TC assessment and MFC in the multicenter phase II randomized FORTE trial for NDTEMM patients, finding no significant correlations between PET/CT negativity after therapy and baseline prognostic factors or PET/ CT characteristics were found.

TL;DR: RCT eligibility in INSIGHT MM is analyzed, with a focus on the treatment of frail MM pts in the real world, and finds that Frail pts are particularly likely to be ineligible for RCTs based on these standard criteria.