Mario Gallorini

TL;DR: The results allowed the proposal of reference values for various elements determined in more than 350 healthy subjects and a "range of uncertainty" and an upper limit above which metabolic abnormalities could be expected have been defined on the basis of simple statistical considerations.

TL;DR: Data suggest that in LC neurons, the iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM, which may explain at least one of the reasons underlying lower vulnerability of LC compared to SN in Parkinsonian syndromes.

TL;DR: It is concluded that neuromelanin is the major iron storage in substantia nigra neurones in normal individuals.

TL;DR: The synthesis of neuromelanins in the various regions of the human brain is an important protective process because the melanic component is generated through the removal of reactive/toxic quinones that would otherwise cause neurotoxicity.

TL;DR: Quantification of the total iron content in iron-loaded NM and synthetic melanin demonstrated that the iron-binding capacity of NM is 10-fold greater than that of the model melanin.