M
Marion Trommsdorff
Researcher at University of Texas Southwestern Medical Center
Publications - 4
Citations - 3161
Marion Trommsdorff is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Very Low-Density Lipoprotein Receptor & Low-density lipoprotein receptor gene family. The author has an hindex of 4, co-authored 4 publications receiving 3058 citations.
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Journal ArticleDOI
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Marion Trommsdorff,Michael Gotthardt,Thomas Hiesberger,John M. Shelton,Walter Stockinger,Johannes Nimpf,Robert E. Hammer,James A. Richardson,Joachim Herz +8 more
TL;DR: It is suggested that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1, a cytosolic protein that activates tyrosine kinases.
Journal ArticleDOI
Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation
Thomas Hiesberger,Marion Trommsdorff,Brian W. Howell,André M. Goffinet,Marc C. Mumby,Jonathan A. Cooper,Joachim Herz +6 more
TL;DR: It is shown that Reelin binds directly and specifically to the ectodomains of VLDLR and ApoER2 in vitro and that blockade of V LDLR and apoE receptor 2 correlates with loss of Reelin-induced tyrosine phosphorylation of Disabled-1 in cultured primary embryonic neurons.
Journal ArticleDOI
Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein
TL;DR: Using yeast 2-hybrid and protein coprecipitation approaches in vitro, it is shown that the neuronal adaptor proteins FE65 and mammalian Disabled bind to the cytoplasmic tails of LRP, LDL receptor, and APP, where they can potentially serve as molecular scaffolds for the assembly of cytosolic multiprotein complexes.
Journal ArticleDOI
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
Michael Gotthardt,Marion Trommsdorff,Matthew F. Nevitt,John M. Shelton,James A. Richardson,Walter Stockinger,Johannes Nimpf,Joachim Herz +7 more
TL;DR: It is shown that binding of DAB1 interferes with receptor internalization suggesting a mechanism by which signaling through this class of receptors might be regulated, implying much broader physiological functions for the LDL receptor family than had previously been appreciated.