Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Marion Trommsdorff,Michael Gotthardt,Thomas Hiesberger,John M. Shelton,Walter Stockinger,Johannes Nimpf,Robert E. Hammer,James A. Richardson,Joachim Herz +8 more
TLDR
It is suggested that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1, a cytosolic protein that activates tyrosine kinases.About:
This article is published in Cell.The article was published on 1999-06-11 and is currently open access. It has received 1233 citations till now. The article focuses on the topics: DAB1 & Low-density lipoprotein receptor-related protein 8.read more
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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Tommaso Simoncini,Ali Hafezi-Moghadam,Derek P. Brazil,Klaus Ley,William W. Chin,James K. Liao +5 more
TL;DR: It is shown that the ER isoform, ERα, binds in a ligand-dependent manner to the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI(3)K).
Journal ArticleDOI
LDL-receptor-related proteins in Wnt signal transduction
Keiko Tamai,Mikhall Semenov,Yolchi Kato,Rebecca Spokony,Chunming Liu,Yu Katsuyama,Fred Hess,Jean Pierre Saint-Jeannet,Xi He +8 more
TL;DR: In Xenopus embryos, LRP6 activated Wnt–Fz signalling, and induced Wnt responsive genes, dorsal axis duplication and neural crest formation, indicating that LRP 6 may be a component of the Wnt receptor complex.
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An LDL-receptor-related protein mediates Wnt signalling in mice.
Kathleen I. Pinson,Jane Brennan,Jane Brennan,Susan J. Monkley,Susan J. Monkley,Brian Avery,William C. Skarnes +6 more
TL;DR: Evidence is presented that a new member of the low-density lipoprotein (LDL)-receptor-related protein family, LRP6, is critical for Wnt signalling in mice, and a genetic enhancement of a Wnt mutant phenotype in mice lacking one functional copy of LRP 6 is shown.
Journal ArticleDOI
LRP: A multifunctional scavenger and signaling receptor
TL;DR: The diverse biological roles of the LRP include functions in lipid metabolism, and also in the homeostasis of proteinases and proteinase inhibitors, cellular entry of viruses and toxins, activation of lysosomal enzymes, cellular signal transduction, and neurotransmission.
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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
TL;DR: There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-β peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors.
References
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Signaling Through Scaffold, Anchoring, and Adaptor Proteins
Tony Pawson,John D. Scott +1 more
TL;DR: The role of scaffold, anchoring, and adaptor proteins that contribute to the specificity of signal transduction events by recruiting active enzymes into signaling networks or by placing enzymes close to their substrates is discussed.
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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
TL;DR: It is demonstrated that src is not required for general cell viability (possibly because of functional overlap with other tyrosine kinases related to src) and an essential role for src in bone formation is uncovered.
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A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
Gabriella D'Arcangelo,Graham G. Miao,Shu-Cheng Chen,Holly D. Soares,James I. Morgan,Tom Curran +5 more
TL;DR: The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
Shun Ishibashi,Michael S. Brown,Joseph L. Goldstein,Robert D. Gerard,Robert E. Hammer,Joachim Herz +5 more
TL;DR: It is concluded that the LDL receptor is responsible in part for the low levels of VLDL, IDL, and LDL in wild-type mice and that adenovirus-encoded LDL receptors can acutely reverse the hypercholesterolemic effects of LDL receptor deficiency.
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Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog
TL;DR: It is shown that Sonic hedgehog (Shh), which is made by Purkinje cells, regulates the division of granule cell precursors (GCPs), and treatment of GCPs with Shh prevents differentiation and induces a potent, long-lasting proliferative response.