M
Marios Politis
Researcher at King's College London
Publications - 167
Citations - 9497
Marios Politis is an academic researcher from King's College London. The author has contributed to research in topics: Parkinson's disease & Serotonergic. The author has an hindex of 47, co-authored 158 publications receiving 7504 citations. Previous affiliations of Marios Politis include Hammersmith Hospital & King's College.
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Journal ArticleDOI
Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: an in vivo [(11)C](R)-PK11195-PET pilot study.
Paolo Giannetti,Marios Politis,Paul Su,Federico Turkheimer,Omar Malik,Shiva Keihaninejad,Kit Wu,Richard Reynolds,Richard Nicholas,Paola Piccini +9 more
TL;DR: The findings show that relapsing and progressive patients have heterogeneous patterns of PKBPND in T1 BHs and indicate that BH's are not just "holes" representing loss of axons and myelin, but display inflammatory activity in the form of activated microglia in disability progression.
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Serotonin transporter in Parkinson's disease: A meta-analysis of positron emission tomography studies.
TL;DR: In this article, the role of SERT in the development of motor and non-motor complications in patients with Parkinson's disease was reviewed and a meta-analysis was performed to identify the patterns of serotonergic pathology and the relevance to symptoms.
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Serotonin-to-dopamine transporter ratios in Parkinson disease: Relevance for dyskinesias
TL;DR: The findings suggest that, when the dopaminergic innervation in the striatum is critically low, the serotonergic system plays an important role in development of LIDs.
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Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study
Heather Wilson,George Dervenoulas,Gennaro Pagano,Robin J. Tyacke,Sotirios Polychronis,Jim Myers,Roger N. Gunn,Roger N. Gunn,Eugenii A. Rabiner,Eugenii A. Rabiner,David J. Nutt,Marios Politis +11 more
TL;DR: In vivo the role of astroglia activation in vivo in patients with Parkinson's disease is demonstrated using 11C-BU99008 PET, a novel radioligand with high specificity and selectivity for imidazoline 2 binding sites.
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Current status of PET imaging in Huntington's disease.
TL;DR: Brain metabolism, postsynaptic dopaminergic function and phosphodiesterase 10A levels were proven to be powerful in assessing disease progression and an integrative multimodal imaging approach combining different techniques should be developed for monitoring potential neuroprotective and preventive treatment in HD.