Marios Politis

TL;DR: It is suggested that abnormal BMI changes over a 12-month period are linked with relatively raised SERT availability in PD on an overall background of decreased 5-HT function and it is conceivable that 5- HT agents could help alleviate abnormal changes in BMI in PD.

TL;DR: The findings indicate that LIDs in PD are associated with higher GP serotonergic function, which may result in further dysregulation of thalamocortical signals and so promote the expression of dyskinesias.

TL;DR: There may be a threshold of SERT-over-DAT availability in the putamen, above which PD patients are likely to become dyskinetic, as reflected by the increase of the SERT–to–DAT ratio over time.

TL;DR: PD patients with ICDs showed increased cortical thickness in medial prefrontal regions and rostral anterior cingulate and frontal pole, and it is speculated that these findings reflect either a pre-existing neural trait vulnerability to impulsivity or the expression of a maladaptive synaptic plasticity under non-physiological dopaminergic stimulation.

TL;DR: Striatal cyclic adenosine monophosphate activity modulates movement and is determined from the balance between its synthesis by adenylate cyclase 5 and its degradation by phosphodiesterase 10A.