Marios Politis

TL;DR: Assessment of dopamine D(2) receptor availability in hypothalamus of patients with idiopathic Parkinson's disease using positron emission tomography with RAC with (11)C-raclopride provides further evidence of dopaminergic dysfunction in the hypothalamus in PD, and this may contribute to the development of sleep, endocrine and autonomic disorders.

TL;DR: The presence of RBD in PD is associated with faster motor progression in patients with greater synuclein and dopaminergic pathology, and with higher risk of cognitive decline in patientsWith greater syn nuclein and amyloid pathology.

TL;DR: Striatal and pallidal loss of PDE10A expression is demonstrated, which is associated with Parkinson's duration and severity of motor symptoms and complications, and this may help improve dopaminergic signalling and striatal output, and therefore alleviate Symptoms and complications of Parkinson's disease.

TL;DR: In this article, the applications of in vivo microglia imaging in neurodegenerative disorders such as Parkinson's disease, Huntington’s disease, Dementias, and Multiple Sclerosis are reviewed.

TL;DR: Despite significant evidence for the utility of neuroim imaging in assessing parkinsonian patients, none of the neuroimaging techniques are specifically recommended for routine use in clinical practice.