Kit Wu

TL;DR: It is suggested that as the disease advances the most troublesome issues that patients perceive are the lack of response to medication and the nonmotor aspects of the disease, highlighting the importance of assessment and patient‐centered management in the follow-up of these patients.

TL;DR: Two patients with Parkinson’s disease, successfully treated with fetal tissue transplants more than a decade ago, developed troublesome involuntary movements, which were determined to be a result of an overabundance of serotonin-using neurons that developed from the graft, and strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease are suggested.

TL;DR: The heightened response of striatal reward circuitry to heterogeneous reward-related visual cues among a group of patients with different impulsive-compulsive behaviours is consistent with a global sensitization to appetitive behaviours with dopaminergic therapy in vulnerable individuals.

TL;DR: The results suggest that progressive non-linear serotonergic dysfunction occurs in PD but it does not determine levels of disability and chronic exposure to dopaminergic therapy does not appear to influence SERT binding.

TL;DR: Striatal serotonergic terminals contribute to LIDs pathophysiology via aberrant processing of exogenous levodopa and release of dopamine as false neurotransmitter in the denervated striatum of PD patients with LIDs, which supports the development of selective serotonin receptor type 1A agonists for use as antidyskinetic agents in PD.