M
Mariusz Z. Ratajczak
Researcher at University of Louisville
Publications - 547
Citations - 29320
Mariusz Z. Ratajczak is an academic researcher from University of Louisville. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 84, co-authored 525 publications receiving 27088 citations. Previous affiliations of Mariusz Z. Ratajczak include University of Zielona Góra & Thomas Jefferson University.
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Journal ArticleDOI
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.
Janina Ratajczak,Katarzyna Miekus,Magdalena Kucia,Jin Zhang,Ryan Reca,Petr Dvorak,Mariusz Z. Ratajczak +6 more
TL;DR: ES-MV isolated from murine ES cells in serum-free cultures significantly enhanced survival and improved expansion of murine HPC, and upregulated the expression of early pluripotent and early hematopoietic stem cells in these cells.
Journal ArticleDOI
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1–CXCR4 Axis
Magda Kucia,Ryan Reca,Katarzyna Miekus,Jens Wanzeck,Wojtek Wojakowski,Anna Janowska-Wieczorek,Janina Ratajczak,Mariusz Z. Ratajczak +7 more
TL;DR: It is suggested that strategies aimed at modulating the SDF‐1–CXCR4 axis could have important clinical applications both in regenerative medicine to deliver normal stem cells to the tissues/organs and in clinical hematology/oncology to inhibit metastasis of cancer stem cells.
Journal ArticleDOI
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.
Anna Janowska-Wieczorek,Marcin Wysoczynski,Marcin Wysoczynski,Jacek Kijowski,Jacek Kijowski,Leah A. Marquez-Curtis,Leah A. Marquez-Curtis,Bogdan Machalinski,Bogdan Machalinski,Janina Ratajczak,Janina Ratajczak,Mariusz Z. Ratajczak,Mariusz Z. Ratajczak +12 more
TL;DR: It is suggested that PMV play an important role in tumor progression/metastasis and angiogenesis in lung cancer.
Journal ArticleDOI
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion.
Magda Kucia,Kacper Jankowski,Ryan Reca,Marcin Wysoczynski,Laura L. Bandura,Daniel J. Allendorf,Jin Zhang,Janina Ratajczak,Mariusz Z. Ratajczak +8 more
TL;DR: The role of the SDF-1–CXCR4 axis in regulating the metastatic behaviour of tumour cells is focused on and the molecular mechanisms that are essential to this process are discussed.
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A population of very small embryonic-like (VSEL) CXCR4 + SSEA-1 + Oct-4 + stem cells identified in adult bone marrow
Magda Kucia,Ryan Reca,F R Campbell,Ewa K. Zuba-Surma,Marcin Majka,Janina Ratajczak,Mariusz Z. Ratajczak +6 more
TL;DR: It is hypothesize that this population of Sca-1+lin−CD45− very small embryonic-like (VSEL) stem cells is deposited early during development in BM and could be a source of pluripotent stem cells for tissue/organ regeneration.