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Anna Janowska-Wieczorek
Researcher at University of Alberta
Publications - 110
Citations - 11244
Anna Janowska-Wieczorek is an academic researcher from University of Alberta. The author has contributed to research in topics: Progenitor cell & Bone marrow. The author has an hindex of 45, co-authored 110 publications receiving 10693 citations. Previous affiliations of Anna Janowska-Wieczorek include Scripps Research Institute & Canadian Red Cross.
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Journal ArticleDOI
Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication.
TL;DR: The pleiotropic effects of MV that are important for communication between cells, as well as the role of MV in carcinogenesis, coagulation, immune responses and modulation of susceptibility/infectability of cells to retroviruses or prions are discussed.
Journal ArticleDOI
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1–CXCR4 Axis
Magda Kucia,Ryan Reca,Katarzyna Miekus,Jens Wanzeck,Wojtek Wojakowski,Anna Janowska-Wieczorek,Janina Ratajczak,Mariusz Z. Ratajczak +7 more
TL;DR: It is suggested that strategies aimed at modulating the SDF‐1–CXCR4 axis could have important clinical applications both in regenerative medicine to deliver normal stem cells to the tissues/organs and in clinical hematology/oncology to inhibit metastasis of cancer stem cells.
Journal ArticleDOI
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.
Anna Janowska-Wieczorek,Marcin Wysoczynski,Marcin Wysoczynski,Jacek Kijowski,Jacek Kijowski,Leah A. Marquez-Curtis,Leah A. Marquez-Curtis,Bogdan Machalinski,Bogdan Machalinski,Janina Ratajczak,Janina Ratajczak,Mariusz Z. Ratajczak,Mariusz Z. Ratajczak +12 more
TL;DR: It is suggested that PMV play an important role in tumor progression/metastasis and angiogenesis in lung cancer.
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Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases.
Bo-Ra Son,Leah A. Marquez-Curtis,Magda Kucia,Marcin Wysoczynski,A. Robert Turner,Janina Ratajczak,Mariusz Z. Ratajczak,Anna Janowska-Wieczorek,Anna Janowska-Wieczorek +8 more
TL;DR: In vitro results suggest that the SDF‐1‐CXCR4 and HGF‐c‐met axes, along with MMPs, may be involved in recruitment of expanded MSCs to damaged tissues.
Journal ArticleDOI
Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner.
Marcin Majka,Marcin Majka,Anna Janowska-Wieczorek,Anna Janowska-Wieczorek,Janina Ratajczak,Janina Ratajczak,Karen Ehrenman,Karen Ehrenman,Zbigniew Pietrzkowski,Zbigniew Pietrzkowski,M. Anna Kowalska,M. Anna Kowalska,Alan M. Gewirtz,Alan M. Gewirtz,Stephen G. Emerson,Stephen G. Emerson,Mariusz Z. Ratajczak,Mariusz Z. Ratajczak +17 more
TL;DR: It is concluded that normal human CD34(+) cells and hematopoietic precursors secrete numerous regulatory molecules that form the basis of intercellular cross-talk networks and regulate in an autocrine and/or a paracrine manner the various stages of normal human hematoiesis.