M
Mark A. Rizzacasa
Researcher at University of Melbourne
Publications - 135
Citations - 2091
Mark A. Rizzacasa is an academic researcher from University of Melbourne. The author has contributed to research in topics: Total synthesis & Enantioselective synthesis. The author has an hindex of 25, co-authored 132 publications receiving 1944 citations. Previous affiliations of Mark A. Rizzacasa include Monash University, Parkville campus & Case Western Reserve University.
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Journal ArticleDOI
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
James E Vince,James E Vince,Dominic De Nardo,Dominic De Nardo,Wenqing Gao,Angelina J. Vince,Cathrine Hall,Kate McArthur,Kate McArthur,Kate McArthur,Daniel S Simpson,Daniel S Simpson,Swarna L Vijayaraj,Swarna L Vijayaraj,Lisa M Lindqvist,Lisa M Lindqvist,Philippe Bouillet,Philippe Bouillet,Mark A. Rizzacasa,Si Ming Man,John Silke,John Silke,Seth L. Masters,Seth L. Masters,Guillaume Lessene,Guillaume Lessene,David C.S. Huang,David C.S. Huang,Daniel H.D. Gray,Daniel H.D. Gray,Benjamin T. Kile,Benjamin T. Kile,Benjamin T. Kile,Feng Shao,Kate E. Lawlor,Kate E. Lawlor +35 more
TL;DR: It is shown that innate immune cells undergoing BAX/BAK-mediated apoptosis have the capacity to generate pro-inflammatory signals and provide an explanation as to why IL-1β activation is often associated with cellular stress, such as during chemotherapy.
Journal ArticleDOI
Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist
TL;DR: Results suggest that the methyl ester and furan ring are required for activity but that the lactone and ketone functionalities are not, and other salvinorins showed negligible binding affinity at the KOR.
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Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A.
TL;DR: Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum by chemical and spectroscopic methods, particularly 1D and 2D NMR.
Journal ArticleDOI
Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.
Timothy E. Adams,Mariana El Sous,Bill C. Hawkins,Sebastian Hirner,Georgina A. Holloway,Mui Ling Khoo,David J. Owen,G. Paul Savage,Peter J. Scammells,Mark A. Rizzacasa +9 more
TL;DR: Total synthesis of the anticancer 1,4-dioxane containing natural products silvestrol and episilvestrol is described by an approach based on the proposed biosynthesis of these novel compounds to find that the stereochemistry of the core was critical for activity.
Journal ArticleDOI
Divinatorins A−C, New Neoclerodane Diterpenoids from the Controlled Sage Salvia divinorum
TL;DR: Three new neoclerodane diterpenoids, divinatorins A-C (7-9), have been isolated from the leaves of Salvia divinorum by spectroscopic methods as derivatives of the antibiotic (-)-hardwickiic acid.