Gregor B. Adams

TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.

TL;DR: It is shown that, through the CaR, the simple ionic mineral content of the niche may dictate the preferential localization of adult mammalian haematopoiesis in bone.

TL;DR: It is shown that adult mouse ovaries rapidly generate hundreds of oocytes, despite a small premeiotic germ cell pool, and bone marrow transplantation restores oocyte production in wild-type mice sterilized by chemotherapy, as well as in ataxia telangiectasia-mutated gene-deficient mice, which are otherwise incapable of making oocytes.

TL;DR: This review provides a conceptual framework and detailed account of the hematopoietic stem cell niche as defined at present and suggests the components are assembling into a more complex view of the niche and may now be amenable to examination as a system and possibly to alteration to affect outcomes in immune regeneration.

TL;DR: It is shown that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration.