M
Mark D. Johnson
Researcher at University of Massachusetts Medical School
Publications - 301
Citations - 18425
Mark D. Johnson is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 60, co-authored 289 publications receiving 16103 citations. Previous affiliations of Mark D. Johnson include National Institutes of Health & Georgetown University Medical Center.
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Journal ArticleDOI
NCBI BLAST: a better web interface
Mark D. Johnson,Irena Zaretskaya,Yan Raytselis,Yuri Merezhuk,Scott D. McGinnis,Thomas L. Madden +5 more
TL;DR: The public interface of BLAST at the NCBI website has recently been reengineered to improve usability and performance, and key new features include simplified search forms, improved navigation, and a list of recent BLAST results.
Journal ArticleDOI
Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis
Marc I. Chimowitz,Michael J. Lynn,Colin P. Derdeyn,Tanya N. Turan,David Fiorella,Bethany F Lane,L. Scott Janis,Helmi L. Lutsep,Stanley L. Barnwell,Michael F. Waters,Brian L. Hoh,J. Maurice Hourihane,Elad I. Levy,Andrei V. Alexandrov,Mark R. Harrigan,David Chiu,Richard P. Klucznik,Joni Clark,Cameron G. McDougall,Mark D. Johnson,G. Lee Pride,Michel T. Torbey,Osama O. Zaidat,Zoran Rumboldt,Harry J. Cloft +24 more
TL;DR: In patients with intracranial arterial stenosis, aggressive medical management was superior to PTAS with the use of the Wingspan stent system, both because the risk of early stroke after PTAS was high and because therisk of stroke with aggressive medical therapy alone was lower than expected.
Journal ArticleDOI
Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne's or Becker's muscular dystrophy
Eric P. Hoffman,Fischbeck Kh,Robert H. Brown,Mark D. Johnson,Medori R,John D. Loike,Jason B. Harris,R Waterston,Brooke M,Linda A. Specht +9 more
TL;DR: These data show the clinical consequences of both quantitative alterations (in Duchenne's and intermediate dystrophy) in a single protein, and the biochemical assay for dystrophin should prove helpful in delineating myopathies that overlap clinically with DuchenNE's and Becker's Dystrophies and shows promise as an accurate diagnostic tool.
Journal ArticleDOI
Aggressive Medical Treatment With or Without Stenting in High-Risk Patients With Intracranial Artery Stenosis (Sammpris): The Final Results of a Randomised Trial
Colin P. Derdeyn,Marc I. Chimowitz,Michael J. Lynn,David Fiorella,Tanya N. Turan,L. Scott Janis,Jean Montgomery,Azhar Nizam,Bethany F Lane,Helmi L. Lutsep,Stanley L. Barnwell,Michael F. Waters,Brian L. Hoh,J. Maurice Hourihane,Elad I. Levy,Andrei V. Alexandrov,Mark R. Harrigan,David Chiu,Richard P. Klucznik,Joni Clark,Cameron G. McDougall,Mark D. Johnson,G. Lee Pride,John R. Lynch,Osama O. Zaidat,Zoran Rumboldt,Harry J. Cloft +26 more
TL;DR: The findings lend support to the use of aggressive medical management rather than PTAS with the Wingspan system in high-risk patients with atherosclerotic intracranial arterial stenosis.
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Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
Domenico Accili,John Drago,John Drago,Eric J. Lee,Mark D. Johnson,Mark D. Johnson,Martha H. Cool,Paola Salvatore,Laureano D. Asico,Pedro A. Jose,Simeon I. Taylor,Heiner Westphal +11 more
TL;DR: To address the question of whether both metabolic and growth-promoting actions of insulin are mediated by the insulin receptor, mice lacking insulin receptors by targeted mutagenesis in embryo-derived stem (ES) cells are generated.