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Aaron E. Lampano
Researcher at Institute for Systems Biology
Publications - 9
Citations - 827
Aaron E. Lampano is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Cancer research. The author has an hindex of 5, co-authored 5 publications receiving 765 citations. Previous affiliations of Aaron E. Lampano include Seattle Biomed & University of Massachusetts Medical School.
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Journal ArticleDOI
Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals.
Vladimir Litvak,Stephen A. Ramsey,Alistair G. Rust,Daniel E. Zak,Kathleen A. Kennedy,Aaron E. Lampano,Matti Nykter,Ilya Shmulevich,Alan Aderem +8 more
TL;DR: This work mathematically modeled transcriptional regulation of the genes encoding interleukin 6 and C/EBPδ and experimentally confirmed the prediction that the combination of an initiate, an amplifier and an attenuator forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4–induced signals.
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Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
Erica Andersen-Nissen,Thomas R. Hawn,Kelly D. Smith,Alex Nachman,Aaron E. Lampano,Satoshi Uematsu,Shizuo Akira,Alan Aderem +7 more
TL;DR: First evidence that TLR5 regulates the innate immune response in the urinary tract and is essential for an effective murine in vivo immune response to an extracellular pathogen is presented.
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Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli
James C. Cronk,Noël C. Derecki,Emily Ji,Yang Xu,Aaron E. Lampano,Igor Smirnov,Wendy Baker,Geoffrey T. Norris,Ioana Marin,Nathan Coddington,Yochai Wolf,Stephen D. Turner,Alan Aderem,Alexander L. Klibanov,Tajie H. Harris,Steffen Jung,Vladimir Litvak,Jonathan Kipnis +17 more
TL;DR: It is found that Mecp2 regulates microglia and macrophage responsiveness to environmental stimuli to promote homeostasis, and Dysfunction of tissue-resident macrophages might contribute to the systemic pathologies observed in Rett syndrome.
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A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
Vladimir Litvak,Alexander V. Ratushny,Alexander V. Ratushny,Aaron E. Lampano,Frank Schmitz,Albert C. Huang,Ayush T. Raman,Alistair G. Rust,Andreas Bergthaler,John D. Aitchison,John D. Aitchison,Alan Aderem +11 more
TL;DR: The data suggest that the FOXO3–IRF7 regulatory circuit represents a novel mechanism for establishing the requisite set points in the interferon pathway that balances the beneficial effects and deleterious sequelae of the antiviral response.
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Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites
Stephen A. Ramsey,Theo A. Knijnenburg,Kathleen A. Kennedy,Daniel E. Zak,Mark Gilchrist,Elizabeth S. Gold,Carrie D. Johnson,Aaron E. Lampano,Vladimir Litvak,Garnet Navarro,Tetyana Stolyar,Alan Aderem,Ilya Shmulevich +12 more
TL;DR: It is found that using HAc data significantly improves the performance of motif-based TF binding site prediction, and within regions of high HAc, local minima of the HAc ChIP-Seq signal are particularly strongly correlated with TF binding locations.