Mark J. Cook

TL;DR: This study showed that intracranial electroencephalographic monitoring is feasible in ambulatory patients with drug-resistant epilepsy and accurate definition of preictal electrical activity might improve understanding of seizure generation and eventually lead to new management strategies.

TL;DR: The clinical application of magnetic resonance imaging (MRI) using a three-dimensional volume technique which allows total hippocampal volume to be measured and symmetry evaluated can demonstrate asymmetry and focal involvement, and help distinguish between hippocampal and frontal pathologies.

TL;DR: The finding of smaller left hippocampal volume in patients with first-episode schizophrenia and affective psychosis does not support the prediction that smaller hippocampi are specific to schizophrenia, but the association of smaller right hippocampal volumes with increased illness duration in chronic schizophrenia suggests either that there is further neurodegeneration after illness onset or that bilateral small hippocampi predict chronicity.

TL;DR: HS-ve PET-positive TLE may be a surgically remediable syndrome distinct from HS+ve TLE, with a pathophysiological basis that primarily involves lateral temporal neocortical rather than mesial temporal structures.

TL;DR: The majority of patients with epilepsy maintain seizure control during pregnancy, and the apparently higher risk of seizures among women treated with ox carbazepine and the more frequent increases in drug load in the oxcarbazepines and lamotrigine cohorts prompts further studies on relationships with pharmacokinetic changes.