Mark J. Howard

TL;DR: The aim of this review is to highlight and summarize recent literature that have contributed insight into the implications of altered membrane composition on amyloid precursor protein (APP) proteolysis, production of Aβ, its internalization in to cells via permeabilization and receptor mediated uptake.

TL;DR: It is demonstrated that hIAPP promotes Aβ oligomerization and formation of small oligomer and large aggregate heterocomplexes, and rIAPP exhibited reductions in Aβ induced neuronal cell death that was independent of its ability to interact with Aβ and form heterocom complex; suggesting mediation by other pathways.

TL;DR: This study has revealed what is likely to be a very large new family of orbitides, uniquely buried alongside albumin and processed by asparaginyl endopeptidase (AEP).

TL;DR: Using a 1H nuclear magnetic resonance approach to metabolomics, the nature of the mouse gut metabolome is explored as well as providing the first insight into the metabolome of an infected cell line, which will spearhead understanding of the Cryptosporidium-host metabolic exchange and provide novel targets for tackling this deadly parasite.

TL;DR: Examination of the interactions between individual components, experimentally and computationally, provided a rationale for the product distribution during each phase of a cascade, resulting in the construction of a biomimetic network in which the presence or absence of different components provides multiple unique pathways to distinct self‐sorted configurations.