Prashant Bharadwaj

TL;DR: Evidence indicating T2D in promoting Aβ and tau mediated neurodegeneration and the potential contributions of Aβand tau in promoting a diabetic phenotype that could further exacerbate neurodegenersation are highlighted.

TL;DR: The amyloid structure and mechanism of Amyloid aggregation are studied, and the role of Ab in AD Pathogenesis is investigated.

TL;DR: It is concluded that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases.

TL;DR: The journey from the discovery of the Aβ peptide in Alzheimer’s disease (AD) brain to the establishment of pre-clinical AD using PET amyloid tracers, a method now serving as the gold standard for developing peripheral diagnostic approaches in the blood and the eye is discussed.

TL;DR: It is proposed that latrepirdine may represent a novel scaffold for discovery of robust pro-autophagic/anti-neurodegeneration compounds, which might yield clinical benefit for synucleinopathies including Parkinson's disease, Lewy body dementia, rapid eye movement (REM) sleep disorder and/or multiple system atrophy, following optimization of its pro- autophagic and pro-NEurogenic activities.