Journal ArticleDOI
Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein.
Prashant Bharadwaj,Prashant Bharadwaj,Tanya Solomon,Chris J. Malajczuk,Ricardo L. Mancera,Mark J. Howard,Damien W. M. Arrigan,Phillip Newsholme,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins +10 more
TLDR
The aim of this review is to highlight and summarize recent literature that have contributed insight into the implications of altered membrane composition on amyloid precursor protein (APP) proteolysis, production of Aβ, its internalization in to cells via permeabilization and receptor mediated uptake.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2018-09-01. It has received 45 citations till now. The article focuses on the topics: Amyloid precursor protein & Protein aggregation.read more
Citations
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Journal ArticleDOI
Current and emerging avenues for Alzheimer's disease drug targets.
Raúl Loera-Valencia,Angel Cedazo-Minguez,Paul-Ariel Kenigsberg,Guylène Page,Ana I. Duarte,P. Giusti,M. Zusso,P. Robert,Giovanni B. Frisoni,Annamaria Cattaneo,Marietta Zille,Johannes Boltze,Nathalie Cartier,Nathalie Cartier,Luc Buée,Gunilla Johansson,Bengt Winblad,Bengt Winblad +17 more
TL;DR: It is proposed that AD could be tackled not only using combination therapies including Aβ and tau, but also considering insulin and cholesterol metabolism, vascular function, synaptic plasticity, epigenetics, neurovascular junction and blood–brain barrier targets that have been studied recently.
Journal ArticleDOI
Plasma membrane integrity in health and disease: significance and therapeutic potential
Catarina Dias,Jesper Nylandsted +1 more
TL;DR: In this paper, the authors focus on the existence of membrane disruptions and repair mechanisms in both physiological and pathological conditions, and across multiple cell types, albeit to different degrees, and emphasise the widespread potential of targeting plasma membrane repair mechanisms for therapeutic purposes.
Journal ArticleDOI
Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells.
Prashant Bharadwaj,Prashant Bharadwaj,Tanya Solomon,Bikash R. Sahoo,Katarzyna Ignasiak,Scott Gaskin,Joanne Rowles,Giuseppe Verdile,Giuseppe Verdile,Mark J. Howard,Mark J. Howard,Charles S. Bond,Ayyalusamy Ramamoorthy,Ralph N. Martins,Ralph N. Martins,Philip Newsholme +15 more
TL;DR: It is demonstrated that hIAPP promotes Aβ oligomerization and formation of small oligomer and large aggregate heterocomplexes, and rIAPP exhibited reductions in Aβ induced neuronal cell death that was independent of its ability to interact with Aβ and form heterocom complex; suggesting mediation by other pathways.
Journal ArticleDOI
Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes
TL;DR: In this article, the spontaneous self-assembly of bio-inspired, custom-produced docosapentaenoyl (DPA) plasmenyl (ether) and ester phospholipids in aqueous environment (pH 7) by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM).
Journal ArticleDOI
Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers.
TL;DR: It is shown that electrostatic interactions play an important role in fibril-bilayer binding and cholesterol modulates this interaction, and the interaction between positive residues and lipid head groups becomes more favorable in the presence of cholesterol.
References
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Journal ArticleDOI
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
Journal ArticleDOI
The MARTINI force field : Coarse grained model for biomolecular simulations
TL;DR: An improved and extended version of the coarse grained lipid model is presented, coined the MARTINI force field, based on the reproduction of partitioning free energies between polar and apolar phases of a large number of chemical compounds to reproduce the free energies of these chemical building blocks.
Journal ArticleDOI
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Christian Haass,Dennis J. Selkoe +1 more
TL;DR: Findings in other neurodegenerative diseases indicate that a broadly similar process of neuronal dysfunction is induced by diffusible oligomers of misfolded proteins.
Journal ArticleDOI
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
Rakez Kayed,Elizabeth Head,Jennifer L. Thompson,Theresa M. McIntire,Saskia Milton,Carl W. Cotman,Charles G. Glabe +6 more
TL;DR: It is shown that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomer regardless of sequence, suggesting they share a common mechanism of toxicity.
Journal ArticleDOI
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
Jeffery B. Klauda,Richard M. Venable,J. Alfredo Freites,Joseph W. O’Connor,Douglas J. Tobias,Carlos Mondragon-Ramirez,Igor Vorobyov,Alexander D. MacKerell,Richard W. Pastor +8 more
TL;DR: The presented lipid FF is developed and applied to phospholipid bilayers with both choline and ethanolamine containing head groups and with both saturated and unsaturated aliphatic chains and is anticipated to be of utility for simulations of pure lipid systems as well as heterogeneous systems including membrane proteins.
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The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease.
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