Tanya Solomon

TL;DR: The aim of this review is to highlight and summarize recent literature that have contributed insight into the implications of altered membrane composition on amyloid precursor protein (APP) proteolysis, production of Aβ, its internalization in to cells via permeabilization and receptor mediated uptake.

TL;DR: It is demonstrated that hIAPP promotes Aβ oligomerization and formation of small oligomer and large aggregate heterocomplexes, and rIAPP exhibited reductions in Aβ induced neuronal cell death that was independent of its ability to interact with Aβ and form heterocom complex; suggesting mediation by other pathways.

TL;DR: Open field locomotion analysis revealed that treatment with the three inhibitors in combination improved the rate of functional recovery of the hind limb (compared to controls) as early as 1-day post-injury, with beneficial effects persisting to 14 days post-Injury, while all three inhibitors were present.

TL;DR: Evidence suggests that a preventative rather than corrective therapeutic approach may be more efficacious in the treatment of HCM, and a clear understanding of mutation‐specific mechanisms may assist in informing the most effective therapeutic mode of action.

TL;DR: In this article, an 11-colour flow cytometry method for analysing brain cells was evaluated in a weight-drop rat model of repeated mild traumatic brain injury (mTBI).